Randomised clinical trial: efficacy and safety of H. pylori eradication treatment with and without Saccharomyces boulardii supplementation.
- 2023-11-06
- RCT · n = 404
- European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 33(3)
- Olga Sjomina
- Inese Poļaka
- Jekaterina Suhorukova
- Reinis Vangravs
- Sergejs Paršutins
- Viktoria Knaze
- Jin Young Park
- Rolando Herrero
- Raul Murillo
- Mārcis Leja
- PubMed: 37942999
- DOI: 10.1097/cej.0000000000000858
- High evidence
- Large Human Trial
- Adults
Intention-to-treat analysis revealed higher eradication rates for 10-day probiotic treatment (70.8% vs. 54.6%, P = 0.022), but not for 14-day. Probiotic subgroups combined showed non-significantly higher efficacy in per-protocol analysis (90.6% vs. 85.0%, P = 0.183).
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 500 mg BID