Saccharomyces cerevisiae and Improved Total Antioxidant Status

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial moderate-sized effects of Saccharomyces cerevisiae supplementation on total antioxidant status. The evidence is based on animal models, particularly broiler chicks, with one study also showing effects in cell-based assays. Doses and study durations varied and were not consistently reported across studies.

Studied populations: broiler chicks, animals (poultry, swine, canine, feline, horses, ruminants), and HepG2 cells (in vitro model of oxidative stress)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). All studies were conducted in animals or cell models; human data are absent.

Generated Jul 12, 2026

3 of 3 papers

Antioxidant Status, Blood Constituents and Immune Response of Broiler Chickens Fed Two Types of Diets with or without Different Concentrations of Active Yeast.
- 2022-02-12
- Clinical Trial · n = 216
- Animals : an open access journal from MDPI 12(4)
- - Youssef A Attia
  - Hanan Al-Khalaifah
  - Hatem S Abd El-Hamid
  - Mohammed A Al-Harthi
  - Salem R Alyileili
  - Ali A El-Shafey
- PubMed: 35203163
- DOI: 10.3390/ani12040453
4 Insights on
- Improved Total Antioxidant Status
- High evidence
supplementation of a regular- or low-density diet with SC at a concentration of 0.02% or 0.04% improved the antioxidant parameters
Effect
Beneficial
Effect size
Moderate
Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.
- 2025-12-12
- Review
- Veterinary sciences 12(12)
- - Sahdeo Prasad
  - Bhaumik Patel
  - Prafulla Kumar
  - Rajiv Lall
- PubMed: 41472171
- DOI: 10.3390/vetsci12121191
13 Insights on
- Improved Total Antioxidant Status
- Low evidence
Postbiotics offer several beneficial effects, including antioxidant, anti-inflammatory, immune-modulatory, and antimicrobial actions. They enhance antioxidant enzymes, neutralize reactive oxygen species, and inhibit lipid peroxidation, thereby protecting tissues from oxidative damage.
Effect
Beneficial
Effect size
Moderate
In vitro digestion and fermentation of ginseng pectic polysaccharide GPS-1 and attenuation of its product on oleic acid-induced oxidative stress in HepG2 cells.
- 2026-02-18
- Frontiers in pharmacology 17
- - Xiwen Sun
  - Li Liu
  - Wenbo Jiao
  - Ting Ren
  - Ran Zhao
  - Zirui Tan
  - Ziye Jiang
  - Jing Wang
  - Bo Li
  - Xiaoyu Zhang
  - Lili Jiao
- PubMed: 41788794
- DOI: 10.3389/fphar.2026.1758770
3 Insights on
- Improved Total Antioxidant Status
- Low evidence
the fermented product GPS-1-I48 exhibited significantly enhanced hepatoprotective activity, increasing SOD, CAT, and GSH-Px activities while reducing MDA and TG levels in HepG2 cells
Effect
Beneficial
Effect size
Moderate
Significant
Yes

Saccharomyces cerevisiae and Improved Total Antioxidant Status

Antioxidant Status, Blood Constituents and Immune Response of Broiler Chickens Fed Two Types of Diets with or without Different Concentrations of Active Yeast.

Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.

In vitro digestion and fermentation of ginseng pectic polysaccharide GPS-1 and attenuation of its product on oleic acid-induced oxidative stress in HepG2 cells.