Saccharomyces cerevisiae and Improved Total Antioxidant Status

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

All 3 studies (100%) reported beneficial effects with moderate effect sizes on total antioxidant status from Saccharomyces cerevisiae supplementation or postbiotic products. However, only 1 study reached statistical significance, and the evidence base consists entirely of animal and in vitro research—no human trials are available.

Caveats: Evidence base is small (only 3 studies)—conclusions should be considered preliminary. Available evidence is overwhelmingly positive, but clinical literature in this area is subject to publication bias. Additionally, many of the included studies did not reach statistical significance, so the true effect may be smaller than the observed direction suggests. Critically, no human trials were identified; all studies involved animals (broiler chicks, rats) or in vitro cell lines, and applicability to humans is uncertain.

Generated Jun 11, 2026

3 of 3 papers

Antioxidant Status, Blood Constituents and Immune Response of Broiler Chickens Fed Two Types of Diets with or without Different Concentrations of Active Yeast.
- 2022-02-12
- Clinical Trial · n = 216
- Animals : an open access journal from MDPI 12(4)
- - Youssef A Attia
  - Hanan Al-Khalaifah
  - Hatem S Abd El-Hamid
  - Mohammed A Al-Harthi
  - Salem R Alyileili
  - Ali A El-Shafey
- PubMed: 35203163
- DOI: 10.3390/ani12040453
4 Insights on
- Improved Total Antioxidant Status
- High evidence
supplementation of a regular- or low-density diet with SC at a concentration of 0.02% or 0.04% improved the antioxidant parameters
Effect
Beneficial
Effect size
Moderate
Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.
- 2025-12-12
- Review
- Veterinary sciences 12(12)
- - Sahdeo Prasad
  - Bhaumik Patel
  - Prafulla Kumar
  - Rajiv Lall
- PubMed: 41472171
- DOI: 10.3390/vetsci12121191
13 Insights on
- Improved Total Antioxidant Status
- Low evidence
Postbiotics offer several beneficial effects, including antioxidant, anti-inflammatory, immune-modulatory, and antimicrobial actions. They enhance antioxidant enzymes, neutralize reactive oxygen species, and inhibit lipid peroxidation, thereby protecting tissues from oxidative damage.
Effect
Beneficial
Effect size
Moderate
In vitro digestion and fermentation of ginseng pectic polysaccharide GPS-1 and attenuation of its product on oleic acid-induced oxidative stress in HepG2 cells.
- 2026-02-18
- Frontiers in pharmacology 17
- - Xiwen Sun
  - Li Liu
  - Wenbo Jiao
  - Ting Ren
  - Ran Zhao
  - Zirui Tan
  - Ziye Jiang
  - Jing Wang
  - Bo Li
  - Xiaoyu Zhang
  - Lili Jiao
- PubMed: 41788794
- DOI: 10.3389/fphar.2026.1758770
3 Insights on
- Improved Total Antioxidant Status
- Low evidence
the fermented product GPS-1-I48 exhibited significantly enhanced hepatoprotective activity, increasing SOD, CAT, and GSH-Px activities while reducing MDA and TG levels in HepG2 cells
Effect
Beneficial
Effect size
Moderate
Significant
Yes

Saccharomyces cerevisiae and Improved Total Antioxidant Status

Antioxidant Status, Blood Constituents and Immune Response of Broiler Chickens Fed Two Types of Diets with or without Different Concentrations of Active Yeast.

Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.

In vitro digestion and fermentation of ginseng pectic polysaccharide GPS-1 and attenuation of its product on oleic acid-induced oxidative stress in HepG2 cells.