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Evidence-Based Supplement Research
Evidence-Based Supplement Research

saccharomyces boulardii and Reduced Diarrhea

Research synthesisHigh evidenceModerate effect9 studies · 9 beneficial · 0 neutral · 0 harmful

Across 9 studies, all reported beneficial effects of Saccharomyces boulardii on reducing diarrhea, with effect sizes ranging from small to large. The predominant effect size is moderate, and the evidence is strongest in clinical populations, particularly those undergoing Helicobacter pylori eradication therapy, pelvic radiotherapy, or antibiotic treatment. The median study duration was 14 days, and the most commonly reported dose was 500 mg four times a day, though doses varied.

  • Effective dose range: 500 mg four times a day
  • Studied populations: Patients with H. pylori infection, patients undergoing pelvic radiotherapy for gynecologic cancers, critically ill tube-fed patients, hospitalized patients

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Most studies were conducted in clinical populations; generalizability to healthy adults is uncertain.

Generated Jul 20, 2026
Doses used in studies
  • mg/day: 250–2,000 (median 1,125, IQR 687.51,562.5) 2 studies
Time to effect
Median: 2 weeks · IQR 2 weeks2 weeks · Range 2 weeks2 weeks — Reported in 1 of 9 studies
Safety in these studies
9 of 9 papers
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