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Evidence-Based Supplement Research
Evidence-Based Supplement Research

saccharomyces boulardii and Reduced Diarrhea

Research synthesisHigh evidenceModerate effect9 studies · 9 beneficial · 0 neutral · 0 harmful

Across 9 studies, all reported beneficial effects of Saccharomyces boulardii on reducing diarrhea, with effect sizes ranging from small to large (predominantly moderate). Evidence comes primarily from clinical populations, including patients with H. pylori infection, those undergoing pelvic radiotherapy, critically ill tube-fed patients, and hospitalized patients. The most studied dose was 250 mg/day to 500 mg four times daily, and the median study duration was 14 days.

  • Effective dose range: 250 mg/day to 500 mg four times daily
  • Studied populations: patients with H. pylori infection, patients undergoing pelvic radiotherapy for gynecologic cancers, critically ill tube-fed patients, hospitalized patients on antibiotics

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Most studies focused on specific clinical populations, so generalizability to healthy individuals or other contexts is uncertain. Only one of nine studies reported duration (14 days), limiting conclusions about longer-term effects.

Generated Jun 20, 2026
Doses used in studies
  • mg/day: 250–2,000 (median 1,125, IQR 687.51,562.5) 2 studies
Time to effect
Median: 2 weeks · IQR 2 weeks2 weeks · Range 2 weeks2 weeks — Reported in 1 of 9 studies
Safety in these studies
9 of 9 papers
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