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Evidence-Based Supplement Research
Evidence-Based Supplement Research

saccharomyces boulardii and Reduced Diarrhea

Research synthesisHigh evidenceModerate effect6 studies · 6 beneficial · 0 neutral · 0 harmful

Across all 6 studies, Saccharomyces boulardii consistently shows beneficial effects for reducing diarrhea, with effect sizes ranging from small to large. Most studies (4 of 6) involved clinical populations (e.g., patients undergoing radiotherapy, critically ill tube-fed patients, or those with Helicobacter pylori infection), and doses ranged from 250 mg/day to 2000 mg/day (500 mg four times daily). The predominant effect size is moderate, though results vary across contexts.

  • Effective dose range: 250-2000 mg/day (most commonly 500 mg four times daily or 250 mg/day)
  • Studied populations: Patients undergoing pelvic radiotherapy, critically ill tube-fed patients, hospitalized patients, and patients with Helicobacter pylori infection

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Study durations were not consistently reported, limiting conclusions about time to effect. Several studies had small sample sizes, and effect sizes varied from small to large across different populations.

Generated May 21, 2026
Doses used in studies
  • mg/day: 250–2,000 (median 1,125, IQR 687.51,562.5) 2 studies
Safety in these studies
6 of 6 papers
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