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Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis.

  • 2025-07-23
  • Frontiers in pharmacology 16
    • Weidong Wu
    • Tianwei Meng
    • Fangfang Jin
    • Junwei Li
    • Jiahao Huang
    • Zhuang Guo
    • Miao Yu
    • Yanyan Zhou

Study Design

Type
Systematic Review
Sample size
n = 928
Population
postmenopausal women from 10 RCTs (928 participants)
Methods
Systematic search of seven electronic databases; meta-analyses using Stata 12.0

Objectives

This meta-analysis aims to systematically evaluate the impact of resveratrol on postmenopausal women.

Methods

We searched seven electronic databases and conducted meta-analyses using Stata 12.0.

Results

Ten randomized controlled trials (RCTs) with 928 participants were identified. Resveratrol significantly reduced pain scores (WMD: -2.841, 95% CI: -5.631 to -0.050, p = 0.046), pain VAS scores (WMD: -7.585, 95% CI: -12.912 to -2.257, p = 0.005), PPI scores (WMD: -8.563, 95% CI: -12.866 to -4.261, p < 0.001), and CTX levels (WMD: -0.137, 95% CI: -0.204 to -0.070, p < 0.001). However, no significant effects were observed on cognition and memory (e.g., PVT, ORR, PSM, RAVLT, LSWM, FSS, DCCS, FICA, TMT), mood (depression, overall mood), metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C), blood pressure, sleep disturbance, menopausal symptoms, SF-36 quality of life, or bone markers ALP and OC.

Conclusion

Resveratrol may improve pain and bone metabolism (CTX) in postmenopausal women but did not affect other examined outcomes. Future large-scale trials are needed to confirm these findings and determine optimal dosing and treatment strategies.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/#myprospero, identifier CRD42024566807.

Research Insights

  • Resveratrol→Improved Cognitive Function

    However, no significant effects were observed on cognition and memory (e.g., PVT, ORR, PSM, RAVLT, LSWM, FSS, DCCS, FICA, TMT)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Improved Insulin Levels

    no significant effects were observed on metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Improved Mood

    no significant effects were observed on mood (depression, overall mood)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced Blood Cholesterol

    no significant effects were observed on metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced Blood Glucose Levels

    no significant effects were observed on metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced Blood Pressure

    no significant effects were observed on blood pressure

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced CTX Level

    Resveratrol significantly reduced CTX levels (WMD: -0.137, 95% CI: -0.204 to -0.070, p < 0.001)

    Effect
    Beneficial
    Effect size
    Small
  • Resveratrol→Reduced Circadian Sleep Disturbance

    no significant effects were observed on sleep disturbance

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced Depression

    no significant effects were observed on mood (depression, overall mood)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced HDL Cholesterol

    no significant effects were observed on metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced HOMA-IR

    no significant effects were observed on metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced Menopausal Symptoms

    no significant effects were observed on menopausal symptoms

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced PPI Score

    Resveratrol significantly reduced PPI scores (WMD: -8.563, 95% CI: -12.866 to -4.261, p < 0.001)

    Effect
    Beneficial
    Effect size
    Small
  • Resveratrol→Reduced Pain Score

    Resveratrol significantly reduced pain scores (WMD: -2.841, 95% CI: -5.631 to -0.050, p = 0.046)

    Effect
    Beneficial
    Effect size
    Small
  • Resveratrol→Reduced Pain Severity

    Resveratrol significantly reduced pain VAS scores (WMD: -7.585, 95% CI: -12.912 to -2.257, p = 0.005)

    Effect
    Beneficial
    Effect size
    Small
  • Resveratrol→Reduced Total Cholesterol Levels

    no significant effects were observed on metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced Triglyceride Levels

    no significant effects were observed on metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C)

    Effect
    Neutral
    Effect size
    Small
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