Resveratrol and Reduced Triglyceride Levels

Research synthesisLow evidenceMixed effect size4 studies · 2 beneficial · 2 neutral · 0 harmful

Across 4 studies (2 systematic reviews and 2 meta-analyses), 2 reported beneficial effects on triglycerides (one moderate, one small) while 2 found no significant effect. The evidence is mixed, with no clear convergence on dose or population.

Caveats: Evidence is mixed – only half of the 4 studies found a significant triglyceride-lowering effect, and effect sizes among positive studies were small to moderate. The largest systematic review (928 postmenopausal women) found no effect, while a meta-analysis in hyperlipidemia showed moderate benefit. The evidence base is small and conclusions should be considered preliminary.

Generated Jul 15, 2026

4 of 4 papersPopulation:

Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis.
- 2025-07-23
- Systematic Review · n = 928
- Frontiers in pharmacology 16
- - Weidong Wu
  - Tianwei Meng
  - Fangfang Jin
  - Junwei Li
  - Jiahao Huang
  - Zhuang Guo
  - Miao Yu
  - Yanyan Zhou
- PubMed: 40771919
- DOI: 10.3389/fphar.2025.1588284
17 Insights on
- Reduced Triglyceride Levels
- High evidence
- Clinical
no significant effects were observed on metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C)
Effect
Neutral
Effect size
Small
Significant
No
Anti-inflammatory mechanism of resveratrol's Triglyceride-lowering effect in hyperlipidemia: a meta-analysis integrated network pharmacology and molecular dynamics simulation.
- 2025-07-24
- Meta-Analysis · n = 337
- Clinical and experimental medicine 25(1)
- - Yinyan Shao
  - Junwei Shi
- PubMed: 40705097
- DOI: 10.1007/s10238-025-01809-6
3 Insights on
- Reduced Triglyceride Levels
- High evidence
Meta-analysis of seven RCTs (n = 337) revealed that RES significantly reduced triglycerides (TG) but showed no significant effects on total cholesterol, low-density lipoprotein, or high-density lipoprotein.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
doses ranged across the included RCTs (not explicitly stated in abstract)
Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.
- 2025-05-29
- Systematic Review · n = 337
- Phytotherapy research : PTR 39(12)
- - Runyu Miao
  - Boxun Zhang
  - Danni Zhou
  - Mengjiao Kang
  - Jiaxing Tian
  - Linhua Zhao
  - Xiaolin Tong
- PubMed: 40439602
- DOI: 10.1002/ptr.8431
12 Insights on
- Reduced Triglyceride Levels
- High evidence
- Clinical
Resveratrol significantly improved … triglycerides (TG) … (P < 0.05)
Effect
Beneficial
Effect size
Small
Significant
Yes
The effects of resveratrol on glycemic indices and lipid profile in patients with type 2 diabetes: an umbrella review and meta-analysis.
- 2026-06-10
- Meta-Analysis
- Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 34(2)
- - Faezeh Ghalichi
  - Roghayeh Molani-Gol
  - Faezeh Tejareh
  - Laleh Payahoo
- PubMed: 42268476
- DOI: 10.1007/s40199-026-00609-x
8 Insights on
- Reduced Triglyceride Levels
- High evidence
- Clinical
no significant effects on triglyceride (TG)
Effect
Neutral
Effect size
Small
Significant
No

Resveratrol and Reduced Triglyceride Levels

Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis.

Anti-inflammatory mechanism of resveratrol's Triglyceride-lowering effect in hyperlipidemia: a meta-analysis integrated network pharmacology and molecular dynamics simulation.

Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.

The effects of resveratrol on glycemic indices and lipid profile in patients with type 2 diabetes: an umbrella review and meta-analysis.