Best Supplements for Reduced Triglyceride Levels
Ranked by research evidence. Compare 104 supplements across 135 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- High evidence5 studies
Across 5 studies, 4 reported beneficial small-to-moderate effects of turmeric/curcumin on reducing triglyceride levels, with 4 statistically significant findings. The predominant effect size was small, with effects typically observed at a median duration of 90 days. The most studied population was adults with metabolic or clinical conditions (e.g., type 2 diabetes, hemodialysis).
- Moderate evidence5 studies
Across 5 studies, 4 reported beneficial effects of L-carnitine on reducing triglyceride levels, with effect sizes ranging from small to large. The predominant effect size is small in the meta-analytic evidence, though one large RCT in women with PCOS showed a large effect. Effects were typically observed over 6 weeks or longer, and most evidence at doses around 2 g/day or more.
Dose: 2000-3000 mg/day - Moderate evidence3 studies
Across 3 studies, 3 reported small beneficial effects of African mango (Irvingia gabonensis) supplementation on reducing triglyceride levels, with 2 of these reaching statistical significance. Evidence comes primarily from a meta-analysis, an RCT (150 mg twice daily for 90 days), and a systematic review, all in clinical populations (metabolic syndrome, overweight/obese adults). Effects are typically observed at 90 days.
Dose: 150 mg twice daily
- HighTurmericAcross 5 studies, 4 reported beneficial small-to-moderate effects of turmeric/curcumin on reducing triglyceride levels, with 4 statistically significant findings. The predominant effect size was small, with effects typically observed at a median duration of 90 days. The most studied population was adults with metabolic or clinical conditions (e.g., type 2 diabetes, hemodialysis).4 beneficial1 neutral5 studies
- ModerateL-CarnitineAcross 5 studies, 4 reported beneficial effects of L-carnitine on reducing triglyceride levels, with effect sizes ranging from small to large. The predominant effect size is small in the meta-analytic evidence, though one large RCT in women with PCOS showed a large effect. Effects were typically observed over 6 weeks or longer, and most evidence at doses around 2 g/day or more. · Dose: 2000-3000 mg/day4 beneficial1 neutral5 studies
- LowVitamin DAcross 4 meta-analyses, 2 reported beneficial small-sized effects of vitamin D supplementation on reducing triglyceride levels, while 2 found neutral results. The beneficial effects were observed in clinical populations (patients with diabetes/prediabetes and metabolic-associated fatty liver disease), but no consistent dose or duration emerged across studies. The overall evidence suggests a small potential benefit, but findings are not uniform.2 beneficial2 neutral4 studies
- ModerateAfrican MangoAcross 3 studies, 3 reported small beneficial effects of African mango (Irvingia gabonensis) supplementation on reducing triglyceride levels, with 2 of these reaching statistical significance. Evidence comes primarily from a meta-analysis, an RCT (150 mg twice daily for 90 days), and a systematic review, all in clinical populations (metabolic syndrome, overweight/obese adults). Effects are typically observed at 90 days. · Dose: 150 mg twice daily2 beneficial1 neutral3 studies
- Lowrice branAcross 3 studies, 1 reported a beneficial moderate-sized effect on reducing triglyceride levels, while 2 found neutral effects. The single beneficial study was a large meta-analysis (n=572) showing a statistically significant reduction of -15.13 mg/dL, but two other meta-analyses and RCTs did not find significant effects. The median study duration was 56 days (8 weeks), based on one study that reported duration.1 beneficial2 neutral3 studies