Best Supplements for Reduced Triglyceride Levels
Ranked by research evidence. Compare 140 supplements across 223 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- High evidence6 studies
Across 6 studies, 5 reported beneficial effects of L-carnitine on reducing triglyceride levels, with one neutral finding and no harmful results. Effect sizes were predominantly small, although one high-quality RCT showed a large effect. The evidence is drawn mainly from meta-analyses and a recent RCT, with a median study duration of 42 days (where reported), suggesting effects can appear within 6 weeks. The most common dose range was around 2–3 g/day, studied primarily in clinical populations such as women with PCOS and adults with metabolic or kidney conditions.
Dose: 2–3 g/day - High evidence6 studies
Across 6 studies, 5 reported beneficial small-sized effects of turmeric/curcumin on reducing triglyceride levels, and 1 study reported a neutral effect. The predominant effect size was small, with statistically significant findings in 5 studies, including multiple meta-analyses. Effects were typically observed at around 90 days, and the most studied population included adults with metabolic or clinical conditions such as type 2 diabetes and hyperglycemia.
- Moderate evidence7 studies
Across 7 studies, 4 reported beneficial small-sized effects of vitamin D supplementation on reducing triglyceride levels, while 3 found neutral effects. The evidence is strongest in clinical populations such as type 2 diabetes, gestational diabetes, and metabolic-associated fatty liver disease. Median study duration was 42 days, but this is based on only 1 study.
Product matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208)
140 supplements
- HighL-CarnitineAcross 6 studies, 5 reported beneficial effects of L-carnitine on reducing triglyceride levels, with one neutral finding and no harmful results. Effect sizes were predominantly small, although one high-quality RCT showed a large effect. The evidence is drawn mainly from meta-analyses and a recent RCT, with a median study duration of 42 days (where reported), suggesting effects can appear within 6 weeks. The most common dose range was around 2–3 g/day, studied primarily in clinical populations such as women with PCOS and adults with metabolic or kidney conditions. · Dose: 2–3 g/day5 beneficial1 neutral6 studies
- HighTurmericAcross 6 studies, 5 reported beneficial small-sized effects of turmeric/curcumin on reducing triglyceride levels, and 1 study reported a neutral effect. The predominant effect size was small, with statistically significant findings in 5 studies, including multiple meta-analyses. Effects were typically observed at around 90 days, and the most studied population included adults with metabolic or clinical conditions such as type 2 diabetes and hyperglycemia.5 beneficial1 neutral6 studies
- ModerateVitamin DAcross 7 studies, 4 reported beneficial small-sized effects of vitamin D supplementation on reducing triglyceride levels, while 3 found neutral effects. The evidence is strongest in clinical populations such as type 2 diabetes, gestational diabetes, and metabolic-associated fatty liver disease. Median study duration was 42 days, but this is based on only 1 study.4 beneficial3 neutral7 studies
- ModerateArtichokeAcross 4 studies, all reported beneficial effects of artichoke supplementation on reducing triglyceride levels, with three studies showing small effects and one showing a moderate effect. All four findings were statistically significant. The most-studied doses range from 600 to 1800 mg daily, and effects were observed in clinical populations such as those with non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome, with a median study duration of 72 days (approximately 10 weeks). · Dose: 600-1800 mg daily4 beneficial4 studies
- Moderaterice branAcross 5 studies, 3 reported beneficial effects on triglyceride reduction, with effect sizes ranging from small to moderate. The highest-quality evidence comes from a 2024 meta-analysis (n=572) showing a moderate beneficial effect (-15.13 mg/dL; 95% CI: -29.56, -0.71). The most-studied dose is 30 g/day of rice bran oil, and effects were typically observed at 8 weeks (median study duration: 56 days). · Dose: 30 g/day3 beneficial2 neutral5 studies
- ModerateFish OilAcross 4 studies, fish oil supplementation showed predominantly small beneficial effects on reducing triglyceride levels (3 of 4 studies beneficial), with one meta-analysis reporting a moderate effect (SMD -0.40). Most studies lasted 8–12 weeks and dosed 600–1000 mg EPA+DHA daily. Effects were observed in clinical populations with metabolic or inflammatory conditions such as MASLD, migraine, and prediabetes.3 beneficial1 neutral4 studies
- Moderatechia seedAcross 4 studies, 3 reported beneficial small-to-large effects of chia seed supplementation on reduced triglyceride levels, with 1 neutral finding. Two meta-analyses (n=500 and n=835) found statistically significant small reductions (g = -0.200; WMD of -8.69 to -13.11 mg/dL), while one small RCT in patients with hypertriglyceridaemia showed a large beneficial effect with 30 g/day over 56 days. Effects typically observed at 8 weeks. · Dose: 30 g/day3 beneficial1 neutral4 studies
- ModerateCinnamonAcross 4 studies, 3 reported beneficial effects of cinnamon supplementation on reduced triglyceride levels, with effect sizes ranging from small to large (predominantly small). The most consistent evidence comes from a large meta-analysis (n=3054) showing a small beneficial effect at doses ≤2 g/day over 30 days in adults with type 2 diabetes. The median study duration was 57 days, and effects were primarily observed in clinical populations with type 2 diabetes or dyslipidemia. · Dose: ≤2 g/day3 beneficial1 neutral4 studies
- ModerateflaxseedAcross all 3 studies in the database, flaxseed supplementation showed beneficial moderate-sized effects on reducing triglyceride levels, with all studies reporting statistically significant findings. Evidence primarily comes from clinical populations (type 2 diabetes and coronary artery disease), and effects were typically observed after 90 days of supplementation, though only one study reported duration. · Dose: 16 g daily (single study reporting dose)3 beneficial3 studies
- ModerateRaspberryAcross all 3 available studies, raspberry-derived ellagic acid showed consistent moderate beneficial effects on reducing triglyceride levels, with statistically significant reductions observed in each trial. The most studied dose range is 180–200 mg/day of ellagic acid, and effects were typically observed over 8 weeks (median 56 days). Populations included individuals with metabolic dysfunction-associated steatotic liver disease (MASLD), non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome. · Dose: 180–200 mg/day of ellagic acid3 beneficial3 studies
- LowOliveAcross all 3 studies available, olive leaf extract (OLE) shows beneficial effects on reducing triglyceride levels, with 2 of 3 studies reporting statistically significant findings and effect sizes ranging from small to moderate. The median study duration was 84 days (12 weeks), suggesting effects typically observed after several weeks of supplementation. The most studied population includes adults with elevated cardiovascular risk or postmenopausal women, with doses ranging from 250 mg/day to 1000 mg/day. · Dose: 250-1000 mg/day3 beneficial3 studies
- ModerateResveratrolAcross 4 studies, 2 reported beneficial effects on triglycerides (moderate effect in one meta-analysis, small in another), while 2 found neutral effects (small effect size). The overall effect direction is mixed, with no clear predominant effect size (small to moderate). Evidence primarily derives from meta-analyses and systematic reviews in clinical populations, including postmenopausal women and patients with type 2 diabetes, but doses and forms were not consistently reported.2 beneficial2 neutral4 studies
- LowBerberineAcross 4 studies, the evidence for berberine reducing triglyceride levels is mixed: 2 studies reported beneficial effects (one with moderate effect size, one with small), while 2 high-quality RCTs (one among Chinese men with hyperlipidemia, one among type 2 diabetes patients) found no difference between berberine and placebo, showing neutral small effects. The median study duration was 84 days (12 weeks), and the most-studied dose was approximately 1000–1200 mg/day. The predominant effect direction is mixed (beneficial and neutral), with a small to moderate effect size observed in the beneficial studies. · Dose: 1000–1200 mg/day2 beneficial2 neutral4 studies
- LowGarlicAcross 4 meta-analyses/reviews, 2 reported statistically significant beneficial effects of garlic on triglyceride levels, with effect sizes ranging from small (e.g., WMD -0.17 mmol/L in dyslipidemia patients) to moderate (SMD -0.66 in metabolic syndrome patients). The other 2 found no significant effect. The overall evidence is mixed, and benefits were observed primarily in clinical populations with metabolic syndrome, dyslipidemia, or type 2 diabetes. No consistent dose or form data were reported across studies.2 beneficial2 neutral4 studies
- ModerateBlack CuminAcross 3 meta-analyses, 2 reported beneficial effects on triglyceride levels, with effect sizes ranging from moderate to large, while 1 study found no significant effect. The most robust evidence comes from a 2025 dose-response meta-analysis (n=5,026), which showed a moderate beneficial effect with doses from 200 to 4600 mg/day over 7 days. Effects predominantly favor supplementation, though the evidence base is small and study durations were short. · Dose: 200 to 4600 mg/day2 beneficial1 neutral3 studies
- LowThistleAcross 3 studies, 2 reported beneficial effects on triglyceride levels, with effect sizes ranging from small to large; 1 study found a neutral effect. The most robust evidence comes from a 2025 systematic review in 1,221 patients with alcoholic liver disease, which observed a large beneficial effect (SMD = -1.29, 95% CI -1.93 to -0.66, statistically significant). The evidence base is small and preliminary, with no consistent dose or form data available.2 beneficial1 neutral3 studies
- LowCuminAcross 3 studies, 2 reported beneficial moderate-sized effects of cumin supplementation on reducing triglyceride levels, while 1 was neutral. Evidence is limited to adults with metabolic disorders or dyslipidemia; no consistent dose or form data were reported across studies.2 beneficial1 neutral3 studies
- LowAfrican MangoAcross 3 studies, 2 reported small beneficial effects of African mango (Irvingia gabonensis) supplementation on reducing triglyceride levels, while 1 meta-analysis found a neutral effect that did not reach statistical significance. The only available study with a specific dose used 150 mg twice daily for 90 days in a clinical population with metabolic syndrome. Effects were predominantly small in magnitude, and the median study duration was 90 days, suggesting effects may be observed after several weeks of supplementation. · Dose: 150 mg twice daily2 beneficial1 neutral3 studies
- LowavocadoAcross 4 studies, only 1 reported a moderate beneficial effect on triglycerides, while 3 found neutral effects. The beneficial study used 1 avocado per day (∼180 g) for 21 days in adults with elevated triglycerides, showing a 17.4% reduction. However, the evidence is predominantly neutral and inconsistent, with most studies showing small non-significant effects.1 beneficial3 neutral4 studies
- Lowgreen teaAcross 3 studies, 1 reported a beneficial moderate-sized effect of green tea on reducing triglyceride levels, while 2 found neutral effects. The beneficial finding came from a meta-analysis showing short-term (<8 weeks) green tea intake at doses below 3000 mg/day significantly reduced triglycerides (SMD: -0.74). Evidence base is small (only 3 studies) — conclusions should be considered preliminary. · Dose: <3000 mg/day1 beneficial2 neutral3 studies
- Very lowReishiAcross 3 studies, 1 reported a small beneficial effect of Reishi (Ganoderma lucidum spore oil) on reducing triglyceride levels, while 2 found neutral results. The beneficial effect was observed in a randomized controlled trial with 110 dyslipidemic participants over 12 weeks, using a spore oil form. The median study duration was 63 days, and effect sizes across all studies were consistently small. The evidence base is very small (only 3 studies), so conclusions are preliminary.1 beneficial2 neutral3 studies