Across 5 studies, 4 reported beneficial effects on triglyceride levels, with effect sizes predominantly small. The median study duration was 70 days (10 weeks), suggesting effects typically observed at 8-12 weeks. Evidence comes from clinical populations including type 2 diabetes, metabolic syndrome, and fatty liver disease.
Caveats: Most studies were short-term (8–12 weeks); longer-term effects are less certain. One study using a lower dose (600 mg/day) in patients with major depressive disorder found no significant effect, suggesting dose and population may influence outcomes. Effect sizes were predominantly small, so clinical significance for triglyceride reduction is modest.
serum TG in FO group significantly decreased
triglycerides [TG, pooled standard mean difference (SMD): -0.40 (95% CI: -0.58 to -0.21)]
Blood lipid indexes TC, LDL-C, and TG were reduced
The mean HbA1c rates and plasma triglyceride levels of krill-oil recipients were lower after the post-intervention. (No significant change reported for fish oil on these outcomes)
FO reduced serum triglycerides, hemoglobin A1c and increased HDL-cholesterol