Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Feasibility of Fish Oil Supplementation on Headache Symptoms and Blood Lipids in Migraine Patients.

  • 2024-12
  • Brain and behavior 14(12)
    • En-Ling Yeh
    • Chun-Pai Yang
    • Shu-Wen Lin
    • Hsueh-Fang Wang

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 47
Population
47 subjects with migraine
Methods
Experimental group subjects took 1 g/time of fish oil (including EPA 900 mg/tablet) after breakfast and dinner. Placebo group subjects took 100% soybean oil twice daily.
Blinding
Double-blind
Duration
12 weeks
Funding
Unclear

Objectives

Migraine is a chronic, recurring, and disabling disease. Fish oil intervention was used to investigate its effects on headache symptoms and blood lipids of migraine patients.

Design

All subjects were collected at the Kuang Tian General Hospital from March 2020 to May 2021. Experimental group subjects took 1 g/time of fish oil (including EPA 900 mg/tablet) after breakfast and dinner. Placebo group subjects took 100% soybean oil twice daily. Before and after the test, the migraine improvement questionnaire was used to analyze headaches during attacks, dietary intake, and headache triggers.

Results

The average age of the 47 subjects in this study was 40.3 ± 9.2 years old, the body mass index (BMI) was 24.3 ± 6.0 kg/m2. At Week 12, subjects in the fish oil group were significantly improved relative to the control group (p < 0.05). Blood lipid indexes TC, LDL-C, and TG were reduced, and the frequency, duration, and pain degree of migraine.

Conclusion

Fish oil may be used as an adjunctive therapeutic food for relieving migraine attack symptoms and blood lipids.

Research Insights

  • Fish Oil→Reduced Headache Duration

    At Week 12, subjects in the fish oil group were significantly improved relative to the control group (p < 0.05). ... the frequency, duration, and pain degree of migraine.

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    1 g/time (including EPA 900 mg/tablet) after breakfast and dinner
  • Fish Oil→Reduced Headache Frequency

    At Week 12, subjects in the fish oil group were significantly improved relative to the control group (p < 0.05). ... the frequency, duration, and pain degree of migraine.

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    1 g/time (including EPA 900 mg/tablet) after breakfast and dinner
  • Fish Oil→Reduced Headache Pain Intensity

    At Week 12, subjects in the fish oil group were significantly improved relative to the control group (p < 0.05). ... the frequency, duration, and pain degree of migraine.

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    1 g/time (including EPA 900 mg/tablet) after breakfast and dinner
  • Fish Oil→Reduced LDL Cholesterol

    Blood lipid indexes TC, LDL-C, and TG were reduced

    Effect
    Beneficial
    Effect size
    Small
    Dose
    1 g/time (including EPA 900 mg/tablet) after breakfast and dinner
  • Fish Oil→Reduced Total Cholesterol

    Blood lipid indexes TC, LDL-C, and TG were reduced

    Effect
    Beneficial
    Effect size
    Small
    Dose
    1 g/time (including EPA 900 mg/tablet) after breakfast and dinner
  • Fish Oil→Reduced Triglyceride Levels

    Blood lipid indexes TC, LDL-C, and TG were reduced

    Effect
    Beneficial
    Effect size
    Small
    Dose
    1 g/time (including EPA 900 mg/tablet) after breakfast and dinner
Back to top