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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Fish Oil and Reduced LDL Cholesterol

Doses used in studies

g/day: 2 (median 2, IQR 2–2) — 1 study
mg/day: 600 (median 600, IQR 600–600) — 1 study

Time to effect

Median: 10 weeks · IQR 9 weeks–11 weeks · Range 8 weeks–2.8 months — Reported in 2 of 2 studies

2 of 2 papers

Feasibility of Fish Oil Supplementation on Headache Symptoms and Blood Lipids in Migraine Patients.
- 2024-12
- RCT · n = 47
- Brain and behavior 14(12)
- - En-Ling Yeh
  - Chun-Pai Yang
  - Shu-Wen Lin
  - Hsueh-Fang Wang
- PubMed: 39643480
- DOI: 10.1002/brb3.70149
6 Insights on
- Reduced LDL Cholesterol
- High evidence
- Clinical
Blood lipid indexes TC, LDL-C, and TG were reduced
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
1 g/time (including EPA 900 mg/tablet) after breakfast and dinner
The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial.
- 2025-07
- RCT · n = 57
- Journal of affective disorders 380
- - Murat Açik
  - Funda Pınar Çakiroğlu
  - Atilla Tekin
  - Aslı Egeli
- PubMed: 40118278
- DOI: 10.1016/j.jad.2025.03.097
10 Insights on
- Reduced LDL Cholesterol
- High evidence
- Clinical
Venous blood samples were collected...to evaluate...LDL-c... (No significant effect reported for this outcome)
Effect
Neutral
Effect size
Small
Significant
No
Dose
600 mg EPA + DHA daily