Best Supplements for Reduced LDL Cholesterol
Ranked by research evidence. Compare 66 supplements across 83 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across 4 studies, all 4 reported beneficial moderate-sized effects of rice bran supplementation on reducing LDL cholesterol, with statistically significant reductions observed in each study. The predominant effect size is moderate, with LDL reductions ranging from approximately 14.6 to 15.1 mg/dL in meta-analyses. Effects were studied primarily in adults with metabolic syndrome or overweight/obesity, at doses around 30 g/day, and the only study reporting duration showed effects at 8 weeks.
Dose: About 30 g/day - Low evidence3 studies
Across all 3 studies, all 3 reported beneficial effects of Lactobacillus plantarum supplementation on LDL cholesterol reduction, with 2 of 3 reaching statistical significance. The predominant effect size is mixed (small to moderate), with the highest-quality meta-analysis reporting a moderate effect (LDL-C reduction of 0.23 mmol/L). The evidence base is small, and no consistent dose range, study duration, or form could be identified from the available data.
- Low evidence4 studies
Across 4 meta-analyses, 1 reported a beneficial small effect of vitamin D supplementation on reducing LDL cholesterol, while 3 found neutral effects. The beneficial effect was observed in patients with diabetes and prediabetes; most studies did not report doses, forms, or durations consistently. Overall, the evidence suggests a predominantly neutral effect with a small magnitude in the one beneficial study.
Product matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208)
- Moderaterice branAcross 4 studies, all 4 reported beneficial moderate-sized effects of rice bran supplementation on reducing LDL cholesterol, with statistically significant reductions observed in each study. The predominant effect size is moderate, with LDL reductions ranging from approximately 14.6 to 15.1 mg/dL in meta-analyses. Effects were studied primarily in adults with metabolic syndrome or overweight/obesity, at doses around 30 g/day, and the only study reporting duration showed effects at 8 weeks. · Dose: About 30 g/day4 beneficial4 studies
- LowLactobacillus plantarumAcross all 3 studies, all 3 reported beneficial effects of Lactobacillus plantarum supplementation on LDL cholesterol reduction, with 2 of 3 reaching statistical significance. The predominant effect size is mixed (small to moderate), with the highest-quality meta-analysis reporting a moderate effect (LDL-C reduction of 0.23 mmol/L). The evidence base is small, and no consistent dose range, study duration, or form could be identified from the available data.3 beneficial3 studies
- LowVitamin DAcross 4 meta-analyses, 1 reported a beneficial small effect of vitamin D supplementation on reducing LDL cholesterol, while 3 found neutral effects. The beneficial effect was observed in patients with diabetes and prediabetes; most studies did not report doses, forms, or durations consistently. Overall, the evidence suggests a predominantly neutral effect with a small magnitude in the one beneficial study.1 beneficial3 neutral4 studies