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Evidence-Based Supplement Research
Evidence-Based Supplement Research

Black Cohosh

Safety profile

10 studies reporting safety data

Across 10 clinical studies, no specific adverse events were quantitatively reported as increased with black cohosh. Three studies found no significant difference in specific safety markers (e.g., circulating hormone levels, overall tolerability), and nine studies described black cohosh as generally well tolerated, with adverse events being minimal or mild. No serious adverse events were attributed to black cohosh in these studies.

Caveats: Many of the included studies had poor reporting on safety or were not primarily designed to assess adverse effects, limiting the reliability of the tolerability conclusions. Evidence is drawn from heterogeneous formulations and study durations, and long-term safety beyond 12 months remains uncharacterized.

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