Black Cohosh and Reduced Vasomotor Symptom

• Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial.

  • 2009-11
  • RCT · n = 89
  • Menopause (New York, N.Y.) 16(6)
  • • Stacie E Geller
    • Lee P Shulman
    • Richard B van Breemen
    • Suzanne Banuvar
    • Ying Zhou
    • Geena Epstein
    • Samad Hedayat
    • Dejan Nikolic
    • Elizabeth C Krause
    • Colleen E Piersen
    • Judy L Bolton
    • Guido F Pauli
    • Norman R Farnsworth

  • PubMed: 19609225
  • DOI: 10.1097/gme.0b013e3181ace49b

  4 Insights on

  • Reduced Vasomotor Symptom

  • High evidence
  • Highly Cited
  • Clinical

  Reductions in number of vasomotor symptoms after a 12-month intervention were as follows: ... red clover (57%), placebo (63%)... with only CEE/MPA differing significantly from placebo. Black cohosh and red clover did not significantly reduce the frequency of vasomotor symptoms as compared with placebo.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  standardized extract, dose not specified

• Complementary therapies for management of menopausal symptoms: a systematic review to inform the update of the International Menopause Society recommendations on women's midlife health.

  • 2026-01-07
  • Systematic Review
  • Climacteric : the journal of the International Menopause Society 29(2)
  • • Alison Maunder
    • Amelia K Mardon
    • Vibhuti Rao
    • Sophia Torkel
    • Najwa-Joelle Metri
    • Jing Liu
    • Guoyan Yang
    • Nora Giese
    • Evangeline Mantzioris
    • Nur K Abdul Jafar
    • Geovanna E Rodrigues de Souza
    • Ieman Al-Kanini
    • Lorena Romero
    • Nick Panay
    • Hugo Pedder
    • Carolyn Ee

  • PubMed: 41498229
  • DOI: 10.1080/13697137.2025.2584061

  2 Insights on

  • Reduced Vasomotor Symptom

  • High evidence
  • Clinical

  moderate-certainty evidence supports black cohosh (vasomotor/menopausal symptoms)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes