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Evidence-Based Supplement Research
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Black Cohosh

Safety profile

8 studies reporting safety data

Across 8 clinical studies, no specific adverse events were quantitatively reported as increased risk for Black Cohosh. The substance was described as well tolerated in 8 studies, with no significant differences in safety markers (e.g., circulating hormone levels) observed in 2 studies. Overall, Black Cohosh was not associated with any elevated risk compared to control based on available trial data.

Caveats: Limited evidence base; absence of adverse event reports does not establish safety. Some studies noted inconclusive safety data due to poor reporting, and long-term safety beyond 12 months is not well characterized. Most studies were not primarily designed to assess safety, so rare adverse events may not have been detected.

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