Resveratrol and Reduced Blood Cholesterol

Research synthesisLow evidenceSmall effect5 studies · 2 beneficial · 3 neutral · 0 harmful

Across 5 studies, 2 reported beneficial small effects on total cholesterol, while 3 found neutral effects (no significant improvement). The predominant effect size is small, and effects were primarily studied in clinical populations (postmenopausal women, overweight adults, and patients with type 2 diabetes). Doses and study durations were not consistently reported across the included reviews.

Studied populations: postmenopausal women, overweight adults, patients with type 2 diabetes mellitus

Caveats: Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Evidence base is small (only 5 studies) — conclusions should be considered preliminary.

Generated Jul 16, 2026

5 of 5 papersPopulation:

Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis.
- 2025-07-23
- Systematic Review · n = 928
- Frontiers in pharmacology 16
- - Weidong Wu
  - Tianwei Meng
  - Fangfang Jin
  - Junwei Li
  - Jiahao Huang
  - Zhuang Guo
  - Miao Yu
  - Yanyan Zhou
- PubMed: 40771919
- DOI: 10.3389/fphar.2025.1588284
17 Insights on
- Reduced Blood Cholesterol
- High evidence
- Clinical
no significant effects were observed on metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C)
Effect
Neutral
Effect size
Small
Significant
No
Anti-inflammatory mechanism of resveratrol's Triglyceride-lowering effect in hyperlipidemia: a meta-analysis integrated network pharmacology and molecular dynamics simulation.
- 2025-07-24
- Meta-Analysis · n = 337
- Clinical and experimental medicine 25(1)
- - Yinyan Shao
  - Junwei Shi
- PubMed: 40705097
- DOI: 10.1007/s10238-025-01809-6
3 Insights on
- Reduced Blood Cholesterol
- High evidence
Meta-analysis of seven RCTs (n = 337) revealed that RES significantly reduced triglycerides (TG) but showed no significant effects on total cholesterol, low-density lipoprotein, or high-density lipoprotein.
Effect
Neutral
Effect size
Small
Significant
No
Dose
doses ranged across the included RCTs (not explicitly stated in abstract)
Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.
- 2025-05-29
- Systematic Review · n = 337
- Phytotherapy research : PTR 39(12)
- - Runyu Miao
  - Boxun Zhang
  - Danni Zhou
  - Mengjiao Kang
  - Jiaxing Tian
  - Linhua Zhao
  - Xiaolin Tong
- PubMed: 40439602
- DOI: 10.1002/ptr.8431
12 Insights on
- Reduced Blood Cholesterol
- High evidence
- Clinical
Resveratrol significantly improved … total cholesterol (TC) … (P < 0.05)
Effect
Beneficial
Effect size
Small
Significant
Yes
Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials.
- 2026-04-15
- Meta-Analysis
- Nutrition journal 25(1)
- - Jia-Nan Sun
  - Rui Yang
  - Li Fang
  - Yun-Jia Li
  - Wei-Yi Xing
  - Ming-Li Sun
  - Lang Wu
  - Qi-Jun Wu
  - Ting-Ting Gong
- PubMed: 41987155
- DOI: 10.1186/s12937-026-01319-5
11 Insights on
- Reduced Blood Cholesterol
- High evidence
- Clinical
total cholesterol among overweight adults (MD = -0.19 mmol/L, 95% CI = -0.32, -0.06)
Effect
Beneficial
Effect size
Small
Significant
Yes
The effects of resveratrol on glycemic indices and lipid profile in patients with type 2 diabetes: an umbrella review and meta-analysis.
- 2026-06-10
- Meta-Analysis
- Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 34(2)
- - Faezeh Ghalichi
  - Roghayeh Molani-Gol
  - Faezeh Tejareh
  - Laleh Payahoo
- PubMed: 42268476
- DOI: 10.1007/s40199-026-00609-x
8 Insights on
- Reduced Blood Cholesterol
- High evidence
- Clinical
no significant effects on total cholesterol (TC)
Effect
Neutral
Effect size
Small
Significant
No

Resveratrol and Reduced Blood Cholesterol

Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis.

Anti-inflammatory mechanism of resveratrol's Triglyceride-lowering effect in hyperlipidemia: a meta-analysis integrated network pharmacology and molecular dynamics simulation.

Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.

Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials.

The effects of resveratrol on glycemic indices and lipid profile in patients with type 2 diabetes: an umbrella review and meta-analysis.