Best Supplements for Reduced Alanine Aminotransferase Level
Ranked by research evidence. Compare 41 supplements across 59 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence6 studies
Across 6 studies (4 beneficial, 2 neutral), thistle (silymarin) shows mixed evidence for reducing alanine aminotransferase (ALT) levels, with effect sizes ranging from small to large. The strongest evidence comes from meta-analyses in clinical populations with liver conditions (NAFLD, alcoholic liver disease, anti-tuberculosis drug-induced liver injury). Median study duration was approximately 15 weeks across the two studies that reported it, but dose information is limited.
- Moderate evidence4 studies
Across 4 studies, all reported beneficial effects of vitamin E on reducing alanine aminotransferase (ALT) levels in patients with non-alcoholic fatty liver disease (NAFLD), with 3 reaching statistical significance. Effect sizes were mixed (small to moderate) across studies. The most studied dose range was 400–1000 IU/day, and effects were typically observed at 8–12 weeks (median study duration 72 days).
Dose: 400–1000 IU/day - Moderate evidence3 studies
Across 3 studies, 2 reported beneficial effects (one moderate, one small) of red grape or its constituents (flavonoids, grape seed extract) on reducing ALT levels, primarily in individuals with NAFLD. The median study duration was 60 days (reported in one study). Evidence is preliminary, with effect sizes ranging from small to moderate.
- ModerateThistleAcross 6 studies (4 beneficial, 2 neutral), thistle (silymarin) shows mixed evidence for reducing alanine aminotransferase (ALT) levels, with effect sizes ranging from small to large. The strongest evidence comes from meta-analyses in clinical populations with liver conditions (NAFLD, alcoholic liver disease, anti-tuberculosis drug-induced liver injury). Median study duration was approximately 15 weeks across the two studies that reported it, but dose information is limited.4 beneficial2 neutral6 studies
- ModerateVitamin EAcross 4 studies, all reported beneficial effects of vitamin E on reducing alanine aminotransferase (ALT) levels in patients with non-alcoholic fatty liver disease (NAFLD), with 3 reaching statistical significance. Effect sizes were mixed (small to moderate) across studies. The most studied dose range was 400–1000 IU/day, and effects were typically observed at 8–12 weeks (median study duration 72 days). · Dose: 400–1000 IU/day4 beneficial4 studies
- ModerateRed GrapeAcross 3 studies, 2 reported beneficial effects (one moderate, one small) of red grape or its constituents (flavonoids, grape seed extract) on reducing ALT levels, primarily in individuals with NAFLD. The median study duration was 60 days (reported in one study). Evidence is preliminary, with effect sizes ranging from small to moderate.2 beneficial1 neutral3 studies
- LowL-CarnitineAcross 3 studies, 2 reported small beneficial effects of L-carnitine on reducing alanine aminotransferase (ALT) levels, while 1 showed a neutral result. The two beneficial findings were statistically significant meta-analyses, with pooled mean differences ranging from -11.99 to -19.71 IU/L. Most evidence comes from adults with chronic liver conditions, and effects were typically observed at a median study duration of 112 days (16 weeks), though dose reporting was limited.2 beneficial1 neutral3 studies
- LowBlack CuminAcross 3 studies (2 meta-analyses, 1 RCT), only 1 large meta-analysis reported a small beneficial effect of black cumin supplementation on reducing alanine aminotransferase (ALT) levels, while 2 studies found no significant effect. The overall effect direction is neutral, with small effect sizes across all studies.1 beneficial2 neutral3 studies