Best Supplements for Reduced Gingival Index
Ranked by research evidence. Compare 22 supplements across 29 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence4 studies
Across 4 studies, 3 reported beneficial effects on gingival index, though the largest meta-analysis (n=315 T2D patients) found no significant effect. Effect sizes were mixed (small to large), with the only RCT showing a large effect using 0.2% propolis mouthwash over 21 days. The evidence base is small and preliminary.
- Low evidence3 studies
Across all 3 studies, Lactobacillus reuteri showed consistent beneficial effects on reducing the Gingival Index (GI), with 3 out of 3 studies reporting statistically significant improvements. The predominant effect size was large in 2 studies and small in 1, with effects typically observed at 90 days (based on the single study reporting duration). Most studies were conducted in clinical populations with periodontal conditions or peri-implantitis, and none specified a standardized dose or form.
- Low evidence3 studies
Across 3 studies, 2 reported beneficial small-sized effects and 1 reported a neutral small-sized effect on reducing gingival index with vitamin C. The only study to reach statistical significance was a narrative review with low evidence quality. The median study duration was 180 days (reported in 1 trial), and populations included adults with periodontal conditions, thin gingival phenotype, or type 2 diabetes.
- LowPropolisAcross 4 studies, 3 reported beneficial effects on gingival index, though the largest meta-analysis (n=315 T2D patients) found no significant effect. Effect sizes were mixed (small to large), with the only RCT showing a large effect using 0.2% propolis mouthwash over 21 days. The evidence base is small and preliminary.3 beneficial1 neutral4 studies
- LowLactobacillus reuteriAcross all 3 studies, Lactobacillus reuteri showed consistent beneficial effects on reducing the Gingival Index (GI), with 3 out of 3 studies reporting statistically significant improvements. The predominant effect size was large in 2 studies and small in 1, with effects typically observed at 90 days (based on the single study reporting duration). Most studies were conducted in clinical populations with periodontal conditions or peri-implantitis, and none specified a standardized dose or form.3 beneficial3 studies
- LowVitamin CAcross 3 studies, 2 reported beneficial small-sized effects and 1 reported a neutral small-sized effect on reducing gingival index with vitamin C. The only study to reach statistical significance was a narrative review with low evidence quality. The median study duration was 180 days (reported in 1 trial), and populations included adults with periodontal conditions, thin gingival phenotype, or type 2 diabetes.2 beneficial1 neutral3 studies