Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Aloe Vera

What does the research say about Aloe Vera?

2 health outcomes synthesised

Research on Aloe Vera has examined its effects on 2 health outcomes, both with low evidence strength. The most studied areas are reducing oral mucositis severity and pain, each supported by 3 studies, showing small to mixed benefits in specific populations such as cancer patients and those with oral ulcers. No consistent effective dose or form has been reported across the research.

Strongest evidence: Both outcomes have low evidence strength based on GRADE criteria. For reducing oral mucositis severity, 2 of 3 studies reported small to moderate beneficial effects in cancer patients, while 1 neutral study in pediatric patients found no benefit. For pain reduction, 2 of 3 studies showed small to moderate benefits in people with recurrent aphthous stomatitis or radiation-induced mucositis, but one meta-analysis found no significant effect.

Mixed or weaker evidence: Both outcomes have low evidence strength and mixed results. The small number of studies (3 per outcome) and inconsistent findings (one neutral per outcome) limit confidence. Effect sizes vary from small to moderate.

Effective dose patterns: No consistent dose or form of Aloe Vera was reported across studies. Effective doses were not systematically documented, making dose recommendations impossible from this evidence base.

Population insights: The research focuses on clinical populations: cancer patients (including pediatric, head and neck) for oral mucositis, and people with recurrent aphthous stomatitis for pain. Benefits may not generalize to other populations.

Notable caveats: All conclusions are preliminary due to the small evidence base (3 studies per outcome) and low evidence strength. One neutral finding in pediatric patients suggests possible subgroup differences. No consistent dosing data are available, and effect sizes are small to moderate.

Frequently asked

  • What is Aloe Vera good for according to research?
    Research suggests Aloe Vera may have small to moderate benefits for reducing oral mucositis severity and pain, but evidence is limited. Specifically, 2 of 3 studies show benefit for each outcome, while 1 study per outcome found no significant effect.
  • What dose of Aloe Vera is typically used in studies?
    No consistent effective dose has been established across studies. Doses and forms (e.g., mouthwash, gel) varied and were not consistently reported, so no specific dose range can be identified from the current evidence.
  • Who benefits most from Aloe Vera?
    The studies focused on specific populations: cancer patients (including pediatric and head and neck cancer) for oral mucositis, and people with recurrent aphthous stomatitis for pain. Benefits may not apply to general or healthy populations.
  • Are there caveats or limitations in the research on Aloe Vera?
    Key limitations include small sample sizes (only 3 studies per outcome), low evidence strength, preliminary conclusions, and lack of consistent dosing. One neutral finding in pediatric patients suggests possible subgroup differences.
  • Does Aloe Vera help reduce oral mucositis severity?
    Yes, 2 of 3 studies reported beneficial effects on reducing oral mucositis severity, with small to moderate effect sizes. However, one neutral study in pediatric patients found no significant benefit, and the evidence base is small.
  • Does Aloe Vera help reduce pain?
    Yes, 2 of 3 studies found pain reduction benefits in people with recurrent aphthous stomatitis or radiation-induced mucositis, but one meta-analysis showed no significant difference. Effect sizes were mixed, and evidence is low-strength.

Safety profile

6 studies reporting safety data

Across 6 clinical studies, no specific adverse events were quantitatively reported for Aloe Vera. The substance was generally described as well tolerated, with mild transient irritation and erythema noted in one study. No serious adverse events were documented, and limited adverse side effects were reported across the studies, indicating overall tolerability in the populations studied.

Caveats: Limited evidence base (6 studies); absence of reported adverse events does not establish safety. Most studies were not primarily designed for safety assessment, and rare adverse events may not be detected. Findings reflect specific formulations used; other extracts or doses may differ.

Most-studied combinations with Aloe Vera

most supplement research is combination research
Also studied with:L-Glutamine (2), Licorice (2), Turmeric (2), Oregon Grape (2), Olive (2), Honey (4), Turmeric (2), Olive Oil (2), Chamomile (4), Parsley (2)

  • Golden Aloe

    By Carlson

    4.2 (106 reviews)
    In Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $42.42
    		In
    iHerb
    $42.42
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • MultiVitamin

    By Kaged

    4.6 (63 reviews)
    In Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $34.99
    		In
    Vitacost
    $37.49
    		In
    Vitamin Shoppe
    $34.99
    		In

  • Total Cleanse

    By Solaray

    4.3 (20 reviews)
    In Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $11.26
    		In
    Vitacost
    $11.26
    		In
    Vitamin Shoppe
    $-
    		Out

  • Super Digestaway

    By Solaray

    4.8 (4.7K reviews)
    In Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $18.26
    		In
    Vitacost
    $18.26
    		In
    Vitamin Shoppe
    $-
    		Out

  • Super Digest Away

    By Solaray

    4.8 (27 reviews)
    In Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $11.54
    		In
    Vitacost
    $11.54
    		In
    Vitamin Shoppe
    $-
    		Out

  • Aloe Vera Phytogel

    By Nature's Answer

    4.7 (799 reviews)
    Out of Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $10.49
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out
Back to top