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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Lack of Efficacy of Pomegranate Supplementation on Insulin Resistance and Sensitivity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2024-11-05
- Meta-Analysis · n = 673
- Phytotherapy research : PTR 39(1)
- - Shao Yin
  - Fengya Zhu
  - Qian Zhou
  - Miao Chen
  - Xia Wang
  - Qiu Chen
- PubMed: 39499092
- DOI: 10.1002/ptr.8362
3 Insights on
- High evidence
The Effect of Black Chokeberry (Aronia melanocarpa) on Human Inflammation Biomarkers and Antioxidant Enzymes: A Systematic Review of Randomized Controlled Trials.
- 2024-11-05
- Systematic Review · n = 1,986
- Nutrition reviews 83(6)
- - Buse Sarıkaya
  - Ezgi Kolay
  - Merve Guney-Coskun
  - Aslı Yiğit-Ziolkowski
  - Şule Aktaç
- PubMed: 39499790
- DOI: 10.1093/nutrit/nuae143
7 Insights on
- High evidence
Clinical, Laboratory, and Molecular Characteristics of Inherited Vitamin K-Dependent Coagulation Factors Deficiency.
- 2024-11-04
- Review
- Seminars in thrombosis and hemostasis 51(02)
- - Salvatore Perrone
  - Simona Raso
  - Mariasanta Napolitano
- PubMed: 39496305
- DOI: 10.1055/s-0044-1792031
1 Insight on
- Reduced Bleeding Episode
- Low evidence
Improved gastrointestinal tolerance and iron status via probiotic use in iron deficiency anaemia patients initiating oral iron replacement: a randomised controlled trial.
- 2024-11-04
- RCT · n = 295
- The British journal of nutrition 132(10)
- - Gokhan Koker
  - Yasin Sahinturk
  - Gulhan Ozcelik Koker
  - Muhammed Ali Coskuner
  - Merve Eren Durmus
  - Mehmet Mutlu Catli
  - Ayhan Hilmi Cekin
- PubMed: 39494607
- DOI: 10.1017/s0007114524002757
5 Insights on
- High evidence
- Large Human Trial
Advances in Yeast Probiotic Production and Formulation for Preventative Health.
- 2024-11-04
- Review
- Microorganisms 12(11)
- - Ghaneshree Moonsamy
  - Yrielle Roets-Dlamini
  - Cebeni Nkosihawukile Langa
  - Santosh Omrajah Ramchuran
- PubMed: 39597622
- DOI: 10.3390/microorganisms12112233
5 Insights on
- Low evidence
The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clinical Trial.
- 2024-11-03
- RCT
- Nutrients 16(21)
- - Araceli Montoya-Estrada
  - Aline Yunuen García-Cortés
  - José Romo-Yañez
  - Guillermo F Ortiz-Luna
  - Arturo Arellano-Eguiluz
  - Aurora Belmont-Gómez
  - Vivian Lopéz-Ugalde
  - Guadalupe León-Reyes
  - Arturo Flores-Pliego
  - Aurora Espejel-Nuñez
  - Juan Mario Solis-Paredes
  - Enrique Reyes-Muñoz
- PubMed: 39519608
- DOI: 10.3390/nu16213775
5 Insights on
- High evidence
- Rigorous Journal
The Role of Probiotics in Modulating Myocardial Infarction and Depression-like Symptoms: A Study on Sex-Specific Responses.
- 2024-11-02
- Biomedicines 12(11)
- - Marc-André Gagné
  - Geneviève Frégeau
  - Roger Godbout
  - Guy Rousseau
- PubMed: 39595077
- DOI: 10.3390/biomedicines12112511
6 Insights on
- Low evidence
The effects of a 6-week intervention with Limosilactobacillus reuteri ATCC PTA 6475 alone and in combination with L. reuteri DSM 17938 on gut barrier function, immune markers, and symptoms in patients with IBS-D-An exploratory RCT.
- 2024-11-01
- RCT
- PloS one 19(11)
- - Julia König
  - María Fernanda Roca Rubio
  - Richard A Forsgård
  - Julia Rode
  - Jakob Axelsson
  - Gianfranco Grompone
  - Robert J Brummer
- PubMed: 39485760
- DOI: 10.1371/journal.pone.0312464
6 Insights on
- High evidence
Probiotics combined with prebiotics alleviated seasonal allergic rhinitis by altering the composition and metabolic function of intestinal microbiota: a prospective, randomized, double-blind, placebo-controlled clinical trial.
- 2024-11-01
- RCT · n = 106
- Frontiers in immunology 15
- - Yangfan Hou
  - Dan Wang
  - Shuru Zhou
  - Caifang Huo
  - Haijuan Chen
  - Fangxia Li
  - Minjuan Ding
  - Hongxin Li
  - Hongyan Zhao
  - Jin He
  - Hongju Da
  - Yu Ma
  - Zhihui Qiang
  - Xiushan Chen
  - Cairong Bai
  - Jing Cui
  - Na Gao
  - Yun Liu
- PubMed: 39555052
- DOI: 10.3389/fimmu.2024.1439830
3 Insights on
- High evidence
- Large Human Trial
Impact of Coconut Oil and Its Bioactive Metabolites in Alzheimer's Disease and Dementia: A Systematic Review and Meta-Analysis.
- 2024-11-01
- Review
- Diseases (Basel, Switzerland) 12(11)
- - Duaa Bafail
  - Abrar Bafail
  - Norah Alshehri
  - Noura Hamdi Alhalees
  - Ahmad Bajarwan
- PubMed: 39589946
- DOI: 10.3390/diseases12110272
1 Insight on
- Improved Cognitive Score
- Low evidence
The effect of green tea on patients with type 2 diabetes mellitus: A meta-analysis.
- 2024-11-01
- Meta-Analysis · n = 722
- Medicine 103(47)
- - Ming-Jie Jia
  - Xing-Ning Liu
  - Ying-Chao Liang
  - De-Liang Liu
  - Hui-Lin Li
- PubMed: 39809182
- DOI: 10.1097/md.0000000000039702
3 Insights on
- High evidence
Effects of Limosilactobacillus reuteri DSM 17938 in neonates exposed to antibiotics: a randomised controlled trial.
- 2024-10-31
- RCT
- Beneficial microbes 16(2)
- - J Lozar Krivec
  - P Bratina
  - A Valcl
  - K Lozar Manfreda
  - A Petrovčič
  - E Benedik
  - T Obermajer
  - B Bogovič Matijašić
  - U Šetina
  - M Rupnik
  - A Mahnič
  - D Paro-Panjan
- PubMed: 39486439
- DOI: 10.1163/18762891-bja00049
3 Insights on
- High evidence
- Rigorous Journal
Astaxanthin improves assisted reproductive technology outcomes in poor ovarian responders through alleviating oxidative stress, inflammation, and apoptosis: a randomized clinical trial.
- 2024-10-31
- RCT
- Journal of ovarian research 17(1)
- - Anahid Shafie
  - Ashraf Aleyasin
  - Mojtaba Saffari
  - Mojtaba Saedi
  - Sahar Rostami
  - Saeede Rezayi
  - Seyed Danial Mohammadi
  - Fardin Amidi
- PubMed: 39482765
- DOI: 10.1186/s13048-024-01537-7
12 Insights on
- High evidence
Longitudinal Fecal Microbiota Profiles in A Cohort of Non-Hospitalized Adolescents and Young Adults with COVID-19: Associations with SARS-CoV-2 Status and Long-Term Fatigue.
- 2024-10-31
- Observational
- Pathogens (Basel, Switzerland) 13(11)
- - Christine Olbjørn
  - Milada Hagen
  - Aina Elisabeth Fossum Moen
  - Lise Beier Havdal
  - Silke Lauren Sommen
  - Lise Lund Berven
  - Espen Thiis-Evensen
  - Tonje Stiansen-Sonerud
  - Joel Selvakumar
  - Vegard Bruun Bratholm Wyller
- PubMed: 39599506
- DOI: 10.3390/pathogens13110953
2 Insights on
- Persistent Fatigue
- Post-COVID Condition
- Low evidence
Practical supplements for prevention and management of migraine attacks: a narrative review.
- 2024-10-30
- Review
- Frontiers in nutrition 11
- - Zahra Hajhashemy
  - Sahar Golpour-Hamedani
  - Niloofar Eshaghian
  - Omid Sadeghi
  - Fariborz Khorvash
  - Gholamreza Askari
- PubMed: 39539367
- DOI: 10.3389/fnut.2024.1433390
1 Insight on
- Reduced Migraine Attack Frequency
- Low evidence
Efficacy of L-Arginine for Preventing Preeclampsia and Improving Maternal and Neonatal Outcomes in High-Risk Pregnancies: A Systematic Review and Meta-Analysis.
- 2024-10-30
- Systematic Review · n = 1,165
- International journal of fertility & sterility 18(4)
- - Fatemeh Naderipour
  - Fariba Keshavarzi
  - Hosna Mirfakhraee
  - Parisa Dini
  - Niousha Jamshidnezhad
  - Nastaran Abolghasem
  - Foroogh Sabzghabaei
  - Fatemeh Shariatinia
- PubMed: 39564822
- DOI: 10.22074/ijfs.2024.2016433.1580
9 Insights on
- High evidence
Effects of Chicken Egg Powder, Bovine Colostrum, and Combination Therapy for the Treatment of Gastrointestinal Disorders.
- 2024-10-29
- Review
- Nutrients 16(21)
- - Raymond John Playford
- PubMed: 39519517
- DOI: 10.3390/nu16213684
4 Insights on
- Moderate evidence
- Rigorous Journal
Reevaluating vitamin C in sepsis and septic shock: a potential benefit in severe cases?
- 2024-10-29
- Review
- Frontiers in medicine 11
- - Abdulrahman Alissa
  - Mohammed A Alrashed
  - Abdulrahman I Alshaya
  - Khalid Al Sulaiman
  - Shmeylan Alharbi
- PubMed: 39540046
- DOI: 10.3389/fmed.2024.1476242
1 Insight on
- Reduced Acute Respiratory Distress Syndrome Risk
- Low evidence
Vitamin E and Non-alcoholic Fatty Liver Disease: Investigating the Evidence Through a Systematic Review.
- 2024-10-29
- Review · n = 11
- Cureus 16(10)
- - Mahlet Abera
  - Suchith B Suresh
  - Aparna Malireddi
  - Sruthi Boddeti
  - Khutaija Noor
  - Mehwish Ansar
  - Iana Malasevskaia
- PubMed: 39610563
- DOI: 10.7759/cureus.72596
3 Insights on
- Low evidence
Flaxseed Lowers Blood Pressure in Hypertensive Subjects: A Meta-Analysis of Randomized Controlled Trials.
- 2024-10-29
- Review
- Clinical nutrition research 13(4)
- - Ezatollah Fazeli Moghadam
  - Leili Khaghani
  - Parivash Shekarchizadeh-Esfahani
- PubMed: 39526211
- DOI: 10.7762/cnr.2024.13.4.295
2 Insights on
- Reduced Diastolic Blood Pressure
- Reduced Systolic Blood Pressure
- Low evidence
Lactiplantibacillus plantarum NMGL2 exopolysaccharide ameliorates DSS-induced IBD in mice mainly by regulation of intestinal tight junction and NF-κB p65 protein expression.
- 2024-10-28
- Frontiers in microbiology 15
- - Zengjia Zhou
  - Min Zhang
  - Mengke Yao
  - Jasra Naseeb
  - Abid Sarwar
  - Zhennai Yang
  - Tariq Aziz
  - Majid Alhomrani
  - Walaa F Alsanie
  - Abdulhakeem S Alamri
- PubMed: 39529667
- DOI: 10.3389/fmicb.2024.1491727
4 Insights on
- Low evidence
The Effect of Algae Supplementation on Anthropometric Indices in Adults: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2024-10-27
- Meta-Analysis
- Nutrition reviews 83(3)
- - Shervin Kazeminejad
  - Pishva Arzhang
  - Mohammadreza Moradi Baniasadi
  - Alireza Hatami
  - Leila Azadbakht
- PubMed: 39461896
- DOI: 10.1093/nutrit/nuae151
6 Insights on
- High evidence
Efficacy of Streptococcus salivarius Blis K12 in the Prevention of Upper Respiratory Tract Infections in Physically Active Individuals: A Randomized Controlled Trial.
- 2024-10-26
- RCT · n = 112
- Microorganisms 12(11)
- - Alexander Bertuccioli
  - Marco Cardinali
  - Matteo Micucci
  - Marco Bruno Luigi Rocchi
  - Chiara Maria Palazzi
  - Giordano Bruno Zonzini
  - Giosuè Annibalini
  - Annalisa Belli
  - Davide Sisti
- PubMed: 39597553
- DOI: 10.3390/microorganisms12112164
5 Insights on
- High evidence
Consumption of a Probiotic Blend with Vitamin D Improves Immunity, Redox, and Inflammatory State, Decreasing the Rate of Aging-A Pilot Study.
- 2024-10-25
- Clinical Trial · n = 14
- Biomolecules 14(11)
- - Judith Félix
  - Adriana Baca
  - Luz Taboada
  - Guillermo Álvarez-Calatayud
  - Mónica De la Fuente
- PubMed: 39595538
- DOI: 10.3390/biom14111360
4 Insights on
- Moderate evidence
Examining the Effect of Peppermint Oil on Postoperative Nausea After Cervical Surgery.
- 2024-10-24
- RCT
- The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 56(6)
- - Nurdan Cetin
  - Gulsah Kose
  - Aykut Gokbel
- PubMed: 39447066
- DOI: 10.1097/jnn.0000000000000790
5 Insights on
- High evidence
Micronutrients, Vitamin D, and Inflammatory Biomarkers in COVID-19: A Systematic Review and Meta-analysis of Causal Inference Studies.
- 2024-10-24
- Meta-Analysis · n = 24
- Nutrition reviews 83(7)
- - Ángela Alcalá-Santiago
  - Miguel Rodriguez-Barranco
  - María-José Sánchez
  - Ángel Gil
  - Belén García-Villanova
  - Esther Molina-Montes
- PubMed: 39449666
- DOI: 10.1093/nutrit/nuae152
2 Insights on
- Increased C-Reactive Protein Levels
- Reduced COVID-19 Infection
- High evidence
Short-Term Effects of Escalating Doses of Cholecalciferol on FGF23 and 24,25(OH)2 Vitamin D Levels: A Preliminary Investigation.
- 2024-10-23
- RCT
- Nutrients 16(21)
- - Jessica Pepe
  - Luciano Colangelo
  - Roberta Pilotto
  - Viviana De Martino
  - Carla Ferrara
  - Alfredo Scillitani
  - Mirella Cilli
  - Salvatore Minisola
  - Ravinder Singh
  - Cristiana Cipriani
- PubMed: 39519433
- DOI: 10.3390/nu16213600
10 Insights on
- High evidence
- Rigorous Journal
The Effects of Bitter Melon ( Mormordica charantia ) on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2024-10-23
- Meta-Analysis · n = 423
- Phytotherapy research : PTR 38(12)
- - Mohammad Reza Amini
  - Niloufar Rasaei
  - Moharam Jalalzadeh
  - Sanaz Pourreza
  - Azita Hekmatdoost
- PubMed: 39444254
- DOI: 10.1002/ptr.8357
4 Insights on
- High evidence
Characterization of a Bifidobacterium animalis subsp. lactis reference strain based on ecology and transcriptomics.
- 2024-10-23
- Applied and environmental microbiology 90(10)
- - Gabriele Andrea Lugli
  - Chiara Argentini
  - Chiara Tarracchini
  - Leonardo Mancabelli
  - Alice Viappiani
  - Rosaria Anzalone
  - Leonora Angelini
  - Giulia Alessandri
  - Giulia Longhi
  - Massimiliano G Bianchi
  - Giuseppe Taurino
  - Ovidio Bussolati
  - Christian Milani
  - Francesca Turroni
  - Marco Ventura
- PubMed: 39235395
- DOI: 10.1128/aem.01080-24
1 Insight on
- Improved Niche Colonization
- Low evidence
- Rigorous Journal
Probiotics and Prebiotics for the Treatment of Irritable Bowel Syndrome-A Narrative Review.
- 2024-10-23
- Review
- Journal of clinical medicine 13(21)
- - Carolina Marques Lopes
  - Cristina Sofia de Jesus Monteiro
  - Ana Paula Duarte
  - Jorge Luiz Dos Santos
- PubMed: 39518476
- DOI: 10.3390/jcm13216337
1 Insight on
- Improved Irritable Bowel Syndrome Symptoms
- Low evidence