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Evidence-Based Supplement Research
Evidence-Based Supplement Research

Best Supplements for Increased 25-hydroxyvitamin D Level

Ranked by research evidence. Compare 3 supplements across 17 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.

Top picks by evidence

  • High evidence14 studies

    Across 14 studies, 12 reported beneficial effects of vitamin D supplementation on increasing 25-hydroxyvitamin D levels, with effect sizes ranging from small to large (most commonly small to moderate). The predominant evidence comes from randomized controlled trials and meta-analyses in clinical populations (e.g., older adults, people with HIV, children), with a median study duration of 90 days. Doses varied widely but commonly ranged from 400 to 4000 IU/day, with some studies using higher weekly or single-dose regimens.

    Dose: 400–4000 IU/day
    Product match
    Viva NaturalsVitamin D3 with Organic Liquid Coconut Oil
    125 mcg · $15.16 · ★5.0 (208)
3 supplements
  • HighVitamin DAcross 14 studies, 12 reported beneficial effects of vitamin D supplementation on increasing 25-hydroxyvitamin D levels, with effect sizes ranging from small to large (most commonly small to moderate). The predominant evidence comes from randomized controlled trials and meta-analyses in clinical populations (e.g., older adults, people with HIV, children), with a median study duration of 90 days. Doses varied widely but commonly ranged from 400 to 4000 IU/day, with some studies using higher weekly or single-dose regimens. · Dose: 400–4000 IU/day12 beneficial2 neutral14 studies
  • Vitamin D32 beneficial2 studies
  • Vitamin D21 beneficial1 study
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