Best Supplements for Increased 25-hydroxyvitamin D Level
Ranked by research evidence. Compare 5 supplements across 23 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- High evidence16 studies
Across 16 studies, 14 reported beneficial effects of vitamin D supplementation on increasing 25-hydroxyvitamin D levels, with 14 statistically significant findings. Effect sizes varied from small to large (predominantly mixed), and effects were typically observed at 8–12 weeks (median study duration 90 days). Doses ranged widely (240–4000 IU/day and weekly boluses up to 50,000 IU), with no single dominant dose or form.
Product matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208) - Moderate evidence3 studies
Across 3 studies, all reported beneficial effects of vitamin D2 on increasing 25-hydroxyvitamin D levels, with large effects in 2 randomized controlled trials and moderate effects in 1 meta-analysis. The median study duration was 57 days (approximately 8 weeks), suggesting effects are typically observed within a similar timeframe. Most-studied populations were clinical (patients with chronic intestinal failure and vitamin D deficiency) and health care workers, with the highest-evidence study using a high intramuscular dose of 600,000 units every two weeks for 10 weeks.
Dose: 600,000 units intramuscularly every two weeks (84-day study); other studies did not report dose
- HighVitamin DAcross 16 studies, 14 reported beneficial effects of vitamin D supplementation on increasing 25-hydroxyvitamin D levels, with 14 statistically significant findings. Effect sizes varied from small to large (predominantly mixed), and effects were typically observed at 8–12 weeks (median study duration 90 days). Doses ranged widely (240–4000 IU/day and weekly boluses up to 50,000 IU), with no single dominant dose or form.14 beneficial2 neutral16 studies
- ModerateVitamin D2Across 3 studies, all reported beneficial effects of vitamin D2 on increasing 25-hydroxyvitamin D levels, with large effects in 2 randomized controlled trials and moderate effects in 1 meta-analysis. The median study duration was 57 days (approximately 8 weeks), suggesting effects are typically observed within a similar timeframe. Most-studied populations were clinical (patients with chronic intestinal failure and vitamin D deficiency) and health care workers, with the highest-evidence study using a high intramuscular dose of 600,000 units every two weeks for 10 weeks. · Dose: 600,000 units intramuscularly every two weeks (84-day study); other studies did not report dose3 beneficial3 studies