The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clinical Trial.

2024-11-03
Nutrients 16(21)
- Araceli Montoya-Estrada
- Aline Yunuen García-Cortés
- José Romo-Yañez
- Guillermo F Ortiz-Luna
- Arturo Arellano-Eguiluz
- Aurora Belmont-Gómez
- Vivian Lopéz-Ugalde
- Guadalupe León-Reyes
- Arturo Flores-Pliego
- Aurora Espejel-Nuñez
- Juan Mario Solis-Paredes
- Enrique Reyes-Muñoz

PubMed: 39519608
DOI: 10.3390/nu16213775

Study Design

Type: Randomized Controlled Trial (RCT)
Population: 46 postmenopausal women with insulin resistance (HOMA-IR > 2.5)
Methods: Randomized, double-blind clinical trial; three treatment groups: resveratrol, resveratrol + vitamin C, or vitamin C
Blinding: Double-blind
Funding: Unclear

Rigorous Journal

In postmenopausal women, due to endocrine changes, there is an increase in oxidative stress (OS) that predisposes them to cardiovascular and metabolic alterations. Sixty-one percent of women in this stage require a primary therapeutic strategy to decrease OS. This study aimed to evaluate the effect of resveratrol and vitamin C on OS in postmenopausal women. A randomized, double-blind clinical trial was carried out. Forty-six postmenopausal women with insulin resistance (HOMA-IR > 2.5) were included and divided into three treatment groups: group A: resveratrol, n = 13; group B: resveratrol + vitamin C, n = 15; and group C: vitamin C, n = 14. Between before and after the antioxidants, group B showed a decrease of 33% in lipohydroperoxides (p = 0.02), and malondialdehyde (MDA) decreased by 26% (p = 0.0007), 32% (p = 0.0001), and 38% (p = 0.0001) in groups A-C, respectively. For protein damage, group B is the most representative, with a decrease of 39% (p = 0.0001). For total antioxidant capacity (TAC), there were significant increases of 30% and 28% in groups B and C, respectively. For HOMA-IR, there were no significant differences among the study groups. Supplementation with this combination of antioxidants significantly decreases markers of OS in postmenopausal women. In addition, it increases TAC by up to 30%.

Research Insights

Resveratrol→Improved Insulin Resistance
For HOMA-IR, there were no significant differences among the study groups.
Effect
Neutral
Effect size
Small
Resveratrol→Increased Total Serum Antioxidant Capacity
For total antioxidant capacity (TAC), there were significant increases of 30% and 28% in groups B and C, respectively.
Effect
Beneficial
Effect size
Moderate
Resveratrol→Reduced Lipid Peroxidation
group B showed a decrease of 33% in lipohydroperoxides (p = 0.02), and malondialdehyde (MDA) decreased by 26% (p = 0.0007), 32% (p = 0.0001), and 38% (p = 0.0001) in groups A-C, respectively.
Effect
Beneficial
Effect size
Moderate
Resveratrol→Reduced Malondialdehyde
malondialdehyde (MDA) decreased by 26% (p = 0.0007), 32% (p = 0.0001), and 38% (p = 0.0001) in groups A-C, respectively.
Effect
Beneficial
Effect size
Moderate
Resveratrol→Reduced Protein Damage
For protein damage, group B is the most representative, with a decrease of 39% (p = 0.0001).
Effect
Beneficial
Effect size
Large
Vitamin C→Improved Insulin Resistance
For HOMA-IR, there were no significant differences among the study groups.
Effect
Neutral
Effect size
Small
Vitamin C→Increased Total Serum Antioxidant Capacity
For total antioxidant capacity (TAC), there were significant increases of 30% and 28% in groups B and C, respectively.
Effect
Beneficial
Effect size
Moderate
Vitamin C→Reduced Lipid Peroxidation
group B showed a decrease of 33% in lipohydroperoxides (p = 0.02), and malondialdehyde (MDA) decreased by 26% (p = 0.0007), 32% (p = 0.0001), and 38% (p = 0.0001) in groups A-C, respectively.
Effect
Beneficial
Effect size
Moderate
Vitamin C→Reduced Malondialdehyde
malondialdehyde (MDA) decreased by 26% (p = 0.0007), 32% (p = 0.0001), and 38% (p = 0.0001) in groups A-C, respectively.
Effect
Beneficial
Effect size
Moderate
Vitamin C→Reduced Protein Damage
For protein damage, group B is the most representative, with a decrease of 39% (p = 0.0001).
Effect
Beneficial
Effect size
Large