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Evidence-Based Supplement Research
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Resveratrol and Increased Total Serum Antioxidant Capacity

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 randomized controlled trials, resveratrol consistently showed beneficial moderate-sized effects on increasing total serum antioxidant capacity (TAC). Effects were observed in clinical populations including postmenopausal women with insulin resistance, patients with head and neck cancer, and women with PCOS, with a median study duration of 72 days. The most-studied dose was 800 mg/day, though one study used 400 mg of liposomal resveratrol daily.

  • Effective dose range: 400-800 mg/day
  • Studied populations: postmenopausal women with insulin resistance, patients with head and neck cancer receiving home enteral nutrition, women with polycystic ovary syndrome (PCOS)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). All three studies were in clinical populations with specific health conditions, so generalizability to healthy adults is uncertain.

Generated Jul 11, 2026
Doses used in studies
  • mg/day: 400–800 (median 600, IQR 500–700) — 2 studies
Time to effect
Median: 10.3 weeks · IQR 9.4 weeks–11.1 weeks · Range 8.6 weeks–2.8 months — Reported in 2 of 3 studies
3 of 3 papers
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