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Evidence-Based Supplement Research
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Resveratrol and Increased Total Serum Antioxidant Capacity

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 randomized controlled trials, resveratrol consistently showed moderate beneficial effects on increasing total serum antioxidant capacity in clinical populations. Effects were observed at dosages ranging from 400 mg to 800 mg daily over 60 to 84 days, with a median study duration of 72 days. The findings are based exclusively on clinical populations with conditions associated with oxidative stress, including postmenopausal women with insulin resistance, head and neck cancer patients, and women with polycystic ovary syndrome.

  • Effective dose range: 400-800 mg/day
  • Studied populations: postmenopausal women with insulin resistance, head and neck cancer patients receiving home enteral nutrition, women with polycystic ovary syndrome

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). All studies were in clinical populations with elevated oxidative stress; generalizability to healthy individuals is uncertain.

Generated Jun 11, 2026
Doses used in studies
  • mg/day: 400–800 (median 600, IQR 500–700) — 2 studies
Time to effect
Median: 10.3 weeks · IQR 9.4 weeks–11.1 weeks · Range 8.6 weeks–2.8 months — Reported in 2 of 3 studies
3 of 3 papers
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