Best Supplements for Increased Total Serum Antioxidant Capacity
Ranked by research evidence. Compare 23 supplements across 31 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence3 studies
Across all 3 studies, Black Cumin (Nigella sativa) supplementation consistently showed beneficial effects on increasing total serum antioxidant capacity (TAC), with 3 out of 3 studies reporting statistically significant improvements. The predominant effect size varied (small to large, with one meta-analysis reporting a large effect and another reporting moderate), and the median study duration was 32 days. Doses ranged from 200 to 4600 mg/day, and most evidence comes from clinical populations with cardiovascular or metabolic conditions.
Dose: 200–4600 mg/day - Low evidence3 studies
Across 3 randomized controlled trials, resveratrol consistently showed beneficial moderate-sized effects on increasing total serum antioxidant capacity (TAC). Effects were observed in clinical populations including postmenopausal women with insulin resistance, patients with head and neck cancer, and women with PCOS, with a median study duration of 72 days. The most-studied dose was 800 mg/day, though one study used 400 mg of liposomal resveratrol daily.
Dose: 400-800 mg/day
- ModerateBlack CuminAcross all 3 studies, Black Cumin (Nigella sativa) supplementation consistently showed beneficial effects on increasing total serum antioxidant capacity (TAC), with 3 out of 3 studies reporting statistically significant improvements. The predominant effect size varied (small to large, with one meta-analysis reporting a large effect and another reporting moderate), and the median study duration was 32 days. Doses ranged from 200 to 4600 mg/day, and most evidence comes from clinical populations with cardiovascular or metabolic conditions. · Dose: 200–4600 mg/day3 beneficial3 studies
- LowResveratrolAcross 3 randomized controlled trials, resveratrol consistently showed beneficial moderate-sized effects on increasing total serum antioxidant capacity (TAC). Effects were observed in clinical populations including postmenopausal women with insulin resistance, patients with head and neck cancer, and women with PCOS, with a median study duration of 72 days. The most-studied dose was 800 mg/day, though one study used 400 mg of liposomal resveratrol daily. · Dose: 400-800 mg/day3 beneficial3 studies