Best Supplements for Increased Total Serum Antioxidant Capacity
Ranked by research evidence. Compare 21 supplements across 28 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence3 studies
Across all 3 studies, black cumin (Nigella sativa) supplementation consistently shows beneficial effects on increasing total serum antioxidant capacity. The predominant effect size is mixed (small to large), with two meta-analyses reporting moderate-to-large effects and one RCT finding a small effect. Study durations ranged from 7 to 56 days (median 32 days), and doses varied widely (200–4600 mg/day) without convergence on a specific form.
Dose: 200–4600 mg/day - Low evidence3 studies
Across 3 randomized controlled trials, resveratrol consistently showed beneficial moderate-sized effects on increasing total serum antioxidant capacity (TAC). Effects were observed in clinical populations including postmenopausal women with insulin resistance, patients with head and neck cancer, and women with PCOS, with a median study duration of 72 days. The most-studied dose was 800 mg/day, though one study used 400 mg of liposomal resveratrol daily.
Dose: 400-800 mg/day
- ModerateBlack CuminAcross all 3 studies, black cumin (Nigella sativa) supplementation consistently shows beneficial effects on increasing total serum antioxidant capacity. The predominant effect size is mixed (small to large), with two meta-analyses reporting moderate-to-large effects and one RCT finding a small effect. Study durations ranged from 7 to 56 days (median 32 days), and doses varied widely (200–4600 mg/day) without convergence on a specific form. · Dose: 200–4600 mg/day3 beneficial3 studies
- LowResveratrolAcross 3 randomized controlled trials, resveratrol consistently showed beneficial moderate-sized effects on increasing total serum antioxidant capacity (TAC). Effects were observed in clinical populations including postmenopausal women with insulin resistance, patients with head and neck cancer, and women with PCOS, with a median study duration of 72 days. The most-studied dose was 800 mg/day, though one study used 400 mg of liposomal resveratrol daily. · Dose: 400-800 mg/day3 beneficial3 studies