Vitamin C and Reduced Lipid Peroxidation

• The effect of co-administration of vitamin E and C supplements on plasma oxidative stress biomarkers and antioxidant capacity: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials with meta-regression.

  • 2025-07-16
  • Meta-Analysis · n = 965
  • Frontiers in immunology 16
  • • Mahdi Moabedi
    • Alireza Milajerdi

  • PubMed: 40740780
  • DOI: 10.3389/fimmu.2025.1547888

  2 Insights on

  • Reduced Lipid Peroxidation

  • High evidence

  We found significant results for MDA [WMD: -0.38, 95% CI: -0.48, -0.28 µg/L, P <0.001], LP [WMD: -1.01, 95% CI: -1.49, -0.54 µg/L, P <0.001]

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  250 to 1000 mg/d

• The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clinical Trial.

  • 2024-11-03
  • RCT
  • Nutrients 16(21)
  • • Araceli Montoya-Estrada
    • Aline Yunuen García-Cortés
    • José Romo-Yañez
    • Guillermo F Ortiz-Luna
    • Arturo Arellano-Eguiluz
    • Aurora Belmont-Gómez
    • Vivian Lopéz-Ugalde
    • Guadalupe León-Reyes
    • Arturo Flores-Pliego
    • Aurora Espejel-Nuñez
    • Juan Mario Solis-Paredes
    • Enrique Reyes-Muñoz

  • PubMed: 39519608
  • DOI: 10.3390/nu16213775

  5 Insights on

  • Reduced Lipid Peroxidation

  • High evidence
  • Rigorous Journal
  • Clinical

  group B showed a decrease of 33% in lipohydroperoxides (p = 0.02), and malondialdehyde (MDA) decreased by 26% (p = 0.0007), 32% (p = 0.0001), and 38% (p = 0.0001) in groups A-C, respectively.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes