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Evidence-Based Supplement Research
Evidence-Based Supplement Research

Best Supplements for Reduced Crying Duration

Ranked by research evidence. Compare 11 supplements across 13 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.

Top picks by evidence

  • Low evidence3 studies

    Across 3 studies, 2 reported beneficial effects, including a large-sized reduction in crying duration (WMD -51.3 h, CI95% -72.2 to -30.5 h, P < 0.0001) from a systematic review of 2242 infants with colic, while one small neutral RCT showed no statistically significant benefit in antibiotic-exposed neonates. The predominant effect size is large in the most robust study, but evidence is limited by the small number of studies. Effects were observed in infants with colic, with a median study duration of 42 days.

11 supplements
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