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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Lactobacillus reuteri DSM 17938 and Reduced Crying Duration

Doses used in studies

CFU/day: 100 million–1 billion (median 100 million, IQR 100 million–550 million) — 3 studies

Time to effect

Median: 6 weeks · IQR 6 weeks–6 weeks · Range 6 weeks–6 weeks — Reported in 1 of 2 studies

2 of 2 papers

Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: Systematic review with network meta-analysis.
- 2017-12
- Systematic Review · n = 2,242
- Medicine 96(51)
- - Pedro Gutiérrez-Castrellón
  - Flavia Indrio
  - Alexis Bolio-Galvis
  - Carlos Jiménez-Gutiérrez
  - Irma Jimenez-Escobar
  - Gabriel López-Velázquez
- PubMed: 29390535
- DOI: 10.1097/md.0000000000009375
2 Insights on
- Reduced Crying Duration
- High evidence
- Infants
L reuteri DSM 17938 [WMD -51.3 h (CI95% -72.2 to -30.5 h), P .0001]
Effect
Beneficial
Effect size
Large
Significant
Yes
Effects of Limosilactobacillus reuteri DSM 17938 in neonates exposed to antibiotics: a randomised controlled trial.
- 2024-10-31
- RCT
- Beneficial microbes 16(2)
- - J Lozar Krivec
  - P Bratina
  - A Valcl
  - K Lozar Manfreda
  - A Petrovčič
  - E Benedik
  - T Obermajer
  - B Bogovič Matijašić
  - U Šetina
  - M Rupnik
  - A Mahnič
  - D Paro-Panjan
- PubMed: 39486439
- DOI: 10.1163/18762891-bja00049
3 Insights on
- Reduced Crying Duration
- High evidence
- Rigorous Journal
- Infants
the probiotic group presented a longer sleep duration and shorter crying time than the control group, but the difference was not statistically significant.
Effect
Neutral
Effect size
Small
Significant
No