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Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: Systematic review with network meta-analysis.

  • 2017-12
  • Medicine 96(51)
    • Pedro Gutiérrez-Castrellón
    • Flavia Indrio
    • Alexis Bolio-Galvis
    • Carlos Jiménez-Gutiérrez
    • Irma Jimenez-Escobar
    • Gabriel López-Velázquez

Study Design

Type
Systematic Review
Sample size
n = 2,242
Population
2242 patients, infants with colic
Methods
network-meta-analysis (NMA) of RCTs published between 1960 and 2015; random effect model; SUCRA analysis

Background

5% to 40% of infants cry excessively, usually accompanied by fussiness and excessive of gas. There are no uniform criteria for treatment of infantile colic. Lactobacillus reuteri DSM 17938 has been used with promising results. The objective of this network-meta-analysis (NMA) is to compare the efficacy of L reuteri DSM 17938 with other interventions for infantile colic.

Methods

RCTs, published between 1960 and 2015 for the treatment of infantile colic were included. Primary outcome was duration of crying after 21 to 28 days of treatment. Different databases were searched. Information was analyzed using control group as central axis. A random effect model was used. Hedges standard mean difference (SMD) and odds ratio (OR) were calculated. A SUCRA analysis was performed to evaluate superiority for each intervention.

Results

32 RCTs were analyzed, including 2242 patients. Studies with L reuteri DSM 17938 versus Ctrl., Diet versus Ctrl. and Acupuncture versus Ctrl. were the most influential studies in the NMA. L reuteri DSM 17938 [WMD -51.3 h (CI95% -72.2 to -30.5 h), P .0001] and dietetic approaches [WMD -37.4 h (CI95% -56.1 to -18.7 h), P .0001] were superior compared to the other treatments.

Conclusions

L reuteri DSM 17938 and some dietetic approaches are better to other interventions for treatment of infantile colic.

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