Best Supplements for Reduced Oxidative Stress
Ranked by research evidence. Compare 63 supplements across 82 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence4 studies
Across 4 studies, 3 reported beneficial effects (moderate to large) on reducing oxidative stress, with 1 neutral finding. The most studied dose was 1000 mg/day in one clinical trial, and effects were typically observed at 12 weeks. Evidence primarily comes from clinical populations such as coronary artery disease patients and older women with sarcopenia.
Dose: 1000 mg/day - Very low evidence5 studies
Across 5 studies, all reported beneficial effects of *Lactobacillus rhamnosus* on reducing oxidative stress, with the predominant effect size being moderate. Two of the five studies reported statistically significant findings. The evidence is drawn primarily from animal and in vitro models (broiler chickens, mice, and cell lines), with no human clinical trials available.
- Very low evidence3 studies
Across 3 studies, all reported beneficial effects on reducing oxidative stress, with effect sizes ranging from small to moderate. The evidence base is very small (only 3 papers, all reviews or preclinical), and no studies provided statistically significant findings or consistent dosing information. Effects were predominantly small, though one animal study showed moderate effects from synbiotic supplementation.
- Very lowLactobacillus rhamnosusAcross 5 studies, all reported beneficial effects of *Lactobacillus rhamnosus* on reducing oxidative stress, with the predominant effect size being moderate. Two of the five studies reported statistically significant findings. The evidence is drawn primarily from animal and in vitro models (broiler chickens, mice, and cell lines), with no human clinical trials available.5 beneficial5 studies
- LowVitamin CAcross 4 studies, 3 reported beneficial effects (moderate to large) on reducing oxidative stress, with 1 neutral finding. The most studied dose was 1000 mg/day in one clinical trial, and effects were typically observed at 12 weeks. Evidence primarily comes from clinical populations such as coronary artery disease patients and older women with sarcopenia. · Dose: 1000 mg/day3 beneficial1 neutral4 studies
- Very lowBifidobacterium plantarumAcross 3 studies, all reported beneficial effects on reducing oxidative stress, with effect sizes ranging from small to moderate. The evidence base is very small (only 3 papers, all reviews or preclinical), and no studies provided statistically significant findings or consistent dosing information. Effects were predominantly small, though one animal study showed moderate effects from synbiotic supplementation.3 beneficial3 studies