Lactobacillus rhamnosus and Reduced Oxidative Stress

Research synthesisLow evidenceModerate effect5 studies · 5 beneficial · 0 neutral · 0 harmful

Across 5 studies (all beneficial), moderate effects on reducing oxidative stress were observed in animal and cell models. No human studies were identified. The predominant effect size was moderate, but only 2 of 5 studies reported statistically significant results.

Caveats: All studies are preclinical (animal or cell models) — human evidence is lacking. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Additionally, many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests.

Generated Jul 11, 2026

5 of 5 papers

Exploring the efficacy of a novel prebiotic-like growth promoter on broiler chicken production performance.
- 2024-03
- Clinical Trial
- Veterinary and animal science 23
- - Zulfqarul Haq
  - Ankur Rastogi
  - Ramesh Kumar Sharma
  - Pratiksha Raghuwanshi
  - Maninder Singh
  - Azmat Alam Khan
  - Syed Mudasir Ahmad
- PubMed: 38283334
- DOI: 10.1016/j.vas.2023.100331
6 Insights on
- Reduced Oxidative Stress
- Moderate evidence
NGPE supplementation also lowered lipid peroxidation (P < 0.01), increased reduced glutathione activity (P < 0.01) in chicken erythrocytes...
Effect
Beneficial
Effect size
Moderate
Significant
Yes
An In Vitro Gut-Liver-Adipose Axis Model to Evaluate the Anti-Obesity Potential of a Novel Probiotic-Polycosanol Combination.
- 2025-06-05
- Foods (Basel, Switzerland) 14(11)
- - Simone Mulè
  - Rebecca Galla
  - Francesca Parini
  - Mattia Botta
  - Sara Ferrari
  - Francesca Uberti
- PubMed: 40509530
- DOI: 10.3390/foods14112003
6 Insights on
- Reduced Oxidative Stress
- Low evidence
Probiotics and polycosanols improved intestinal integrity, increased butyrate production, and reduced ROS levels.
Effect
Beneficial
Effect size
Small
Lactiplantibacillus plantarum NMGL2 exopolysaccharide ameliorates DSS-induced IBD in mice mainly by regulation of intestinal tight junction and NF-κB p65 protein expression.
- 2024-10-28
- Frontiers in microbiology 15
- - Zengjia Zhou
  - Min Zhang
  - Mengke Yao
  - Jasra Naseeb
  - Abid Sarwar
  - Zhennai Yang
  - Tariq Aziz
  - Majid Alhomrani
  - Walaa F Alsanie
  - Abdulhakeem S Alamri
- PubMed: 39529667
- DOI: 10.3389/fmicb.2024.1491727
4 Insights on
- Reduced Oxidative Stress
- Low evidence
the nitric oxide (NO) and malondialdehyde (MDA) levels decreased significantly (p < 0.05), while superoxide dismutase (SOD) and glutathione (GSH) levels increased significantly (p < 0.05) after the EPS intervention
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway.
- 2023-03-06
- Journal of animal science and biotechnology 14(1)
- - Jinze Li
  - Qiuke Li
  - Qianhui Wu
  - Nan Gao
  - Zhihua Wang
  - Yang Yang
  - Anshan Shan
- PubMed: 36872332
- DOI: 10.1186/s40104-023-00830-7
6 Insights on
- Reduced Oxidative Stress
- Low evidence
High-dose EPSs were more effective than penicillin for alleviating ileal oxidative damage induced by S.T.
Effect
Beneficial
Effect size
Moderate
Isolation, characterization and anti-UVB irradiation activity of an extracellular polysaccharide produced by Lacticaseibacillus rhamnosus VHPriobi O17.
- 2022-10
- Heliyon 8(10)
- - Shudong Peng
  - Chaoqun Guo
  - Songjie Wu
  - Zhi Duan
- PubMed: 36299523
- DOI: 10.1016/j.heliyon.2022.e11125
4 Insights on
- Reduced Oxidative Stress
- Low evidence
The EPS (OP-2) can effectively alleviate HaCaT cells apoptosis and overproduction of reactive oxygen species (ROS) induced by UVB.
Effect
Beneficial
Effect size
Moderate

Lactobacillus rhamnosus and Reduced Oxidative Stress

Exploring the efficacy of a novel prebiotic-like growth promoter on broiler chicken production performance.

An In Vitro Gut-Liver-Adipose Axis Model to Evaluate the Anti-Obesity Potential of a Novel Probiotic-Polycosanol Combination.

Lactiplantibacillus plantarum NMGL2 exopolysaccharide ameliorates DSS-induced IBD in mice mainly by regulation of intestinal tight junction and NF-κB p65 protein expression.

Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway.

Isolation, characterization and anti-UVB irradiation activity of an extracellular polysaccharide produced by Lacticaseibacillus rhamnosus VHPriobi O17.