Best Supplements for Improved Immune Modulation
Ranked by research evidence. Compare 11 supplements across 20 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence5 studies
Across 5 studies, all reported beneficial effects of Lactobacillus acidophilus L-92 on immune modulation, with a predominant moderate effect size. The evidence includes a statistically significant finding of enhanced phagocytic activity and IFN-γ production in human immune cells, as well as anti-allergic effects via increased IL-12, IFN-γ, and IL-10 and decreased IL-4 from splenocytes. Most studies were reviews focusing on animal populations or general probiotic mechanisms, and doses and study durations were not reported.
- Low evidence3 studies
Across 3 review papers, all reported beneficial effects for improved immune modulation associated with Lactobacillus salivarius UCC118, demonstrating a predominant small effect size. The evidence base consists entirely of review articles, and specific dosing parameters, study populations, forms, and durations were not consistently reported or extracted from the data.
- Very low evidence3 studies
Across 3 review studies, all 3 reported beneficial moderate-sized effects of Bifidobacterium plantarum on immune modulation. However, no studies provided dose, duration, population, or statistical significance data, and all were narrative reviews, not original clinical trials. The evidence base is too limited to draw specific conclusions about dose, duration, or populations.
- LowLactobacillus acidophilus L-92Across 5 studies, all reported beneficial effects of Lactobacillus acidophilus L-92 on immune modulation, with a predominant moderate effect size. The evidence includes a statistically significant finding of enhanced phagocytic activity and IFN-γ production in human immune cells, as well as anti-allergic effects via increased IL-12, IFN-γ, and IL-10 and decreased IL-4 from splenocytes. Most studies were reviews focusing on animal populations or general probiotic mechanisms, and doses and study durations were not reported.5 beneficial5 studies
- LowLactobacillus salivarius UCC118Across 3 review papers, all reported beneficial effects for improved immune modulation associated with Lactobacillus salivarius UCC118, demonstrating a predominant small effect size. The evidence base consists entirely of review articles, and specific dosing parameters, study populations, forms, and durations were not consistently reported or extracted from the data.3 beneficial3 studies
- Very lowBifidobacterium plantarumAcross 3 review studies, all 3 reported beneficial moderate-sized effects of Bifidobacterium plantarum on immune modulation. However, no studies provided dose, duration, population, or statistical significance data, and all were narrative reviews, not original clinical trials. The evidence base is too limited to draw specific conclusions about dose, duration, or populations.3 beneficial3 studies