Best Supplements for Improved Immune Modulation
Ranked by research evidence. Compare 10 supplements across 19 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence5 studies
Across 5 studies, all reported beneficial effects of Lactobacillus acidophilus L-92 on immune modulation, with a predominant moderate effect size. Most evidence comes from reviews and animal studies, with one human-relevant study showing statistically significant increases in phagocytic activity and IFN-γ production. Doses and study durations were not consistently reported, limiting specificity.
- Very low evidence3 studies
Across all 3 studies (all reviews), beneficial effects of Lactobacillus salivarius UCC118 or its derivatives on immune modulation were reported. The predominant effect size was small. No specific dose, form, or population data were available from these studies.
- Very low evidence3 studies
Across all 3 available studies (all beneficial), moderate-sized effects on immune modulation are reported. However, the evidence base is comprised entirely of narrative reviews that do not report participant-level data, doses, or conventional significance testing. No specific dose range or population can be identified from this evidence.
- LowLactobacillus acidophilus L-92Across 5 studies, all reported beneficial effects of Lactobacillus acidophilus L-92 on immune modulation, with a predominant moderate effect size. Most evidence comes from reviews and animal studies, with one human-relevant study showing statistically significant increases in phagocytic activity and IFN-γ production. Doses and study durations were not consistently reported, limiting specificity.5 beneficial5 studies
- Very lowLactobacillus salivarius UCC118Across all 3 studies (all reviews), beneficial effects of Lactobacillus salivarius UCC118 or its derivatives on immune modulation were reported. The predominant effect size was small. No specific dose, form, or population data were available from these studies.3 beneficial3 studies
- Very lowBifidobacterium plantarumAcross all 3 available studies (all beneficial), moderate-sized effects on immune modulation are reported. However, the evidence base is comprised entirely of narrative reviews that do not report participant-level data, doses, or conventional significance testing. No specific dose range or population can be identified from this evidence.3 beneficial3 studies