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Evidence-Based Supplement Research
Evidence-Based Supplement Research

Best Supplements for Improved Immune Modulation

Ranked by research evidence. Compare 11 supplements across 20 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.

Top picks by evidence

  • Low evidence5 studies

    Across 5 studies, all 5 reported beneficial effects of Lactobacillus acidophilus L-92 on immune modulation, with moderate effect sizes predominating. One study reported a statistically significant finding. The evidence is based largely on review articles and preclinical research, with no consistent dose or duration data available.

  • Low evidence3 studies

    Across 3 review studies, all reported beneficial moderate-sized effects for the immunomodulatory properties of probiotics, including Bifidobacterium plantarum. The evidence base is small and limited to review articles without original data on dose, population, or statistical significance. No specific dose range or population could be identified.

    Product match
    California Gold NutritionLactoBif 100 Probiotics
    · $32.35 · ★4.7 (17,687)
  • Very low evidence3 studies

    Across 3 review studies, all reported beneficial but small-sized effects of Lactobacillus salivarius UCC118 on immune modulation. The evidence base is limited to narrative reviews, with no quantitative effect sizes or statistically significant findings reported, and no consistent dose, form, or population data available.

    Product match
    MetagenicsUltraFlora Integrity
    20 mg · $67.50
11 supplements
  • LowLactobacillus acidophilus L-92Across 5 studies, all 5 reported beneficial effects of Lactobacillus acidophilus L-92 on immune modulation, with moderate effect sizes predominating. One study reported a statistically significant finding. The evidence is based largely on review articles and preclinical research, with no consistent dose or duration data available.5 beneficial5 studies
  • LowBifidobacterium plantarumAcross 3 review studies, all reported beneficial moderate-sized effects for the immunomodulatory properties of probiotics, including Bifidobacterium plantarum. The evidence base is small and limited to review articles without original data on dose, population, or statistical significance. No specific dose range or population could be identified.3 beneficial3 studies
  • Very lowLactobacillus salivarius UCC118Across 3 review studies, all reported beneficial but small-sized effects of Lactobacillus salivarius UCC118 on immune modulation. The evidence base is limited to narrative reviews, with no quantitative effect sizes or statistically significant findings reported, and no consistent dose, form, or population data available.3 beneficial3 studies
  • Lactobacillus rhamnosus CLR15051 beneficial1 study
  • Lactobacillus brevis SBC88031 beneficial1 study
  • Berberine1 beneficial1 study
  • saccharomyces boulardii1 beneficial1 study
  • Bifidobacterium lactis HN0191 beneficial1 study
  • Bifidobacterium bifidum Bb-021 beneficial1 study
  • Bifidobacterium lactis Bb-021 beneficial1 study
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