Bifidobacterium plantarum and Improved Immune Modulation

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 review studies, all reported beneficial moderate-sized effects for the immunomodulatory properties of probiotics, including Bifidobacterium plantarum. The evidence base is small and limited to review articles without original data on dose, population, or statistical significance. No specific dose range or population could be identified.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). All studies are narrative reviews, not original clinical trials — effect estimates are based on cited literature rather than direct experimental data.

Generated Jun 11, 2026

3 of 3 papers

Probiotics and human health: biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - a comprehensive review.
- 2026-03-24
- Review
- Frontiers in immunology 16
- - Mohamed T El-Saadony
  - Ahmed M Saad
  - Mahmoud Sitohy
  - Samar Sami Alkafaas
  - Mthokozisi Dladla
  - Soumya Ghosh
  - Dina Mostafa Mohammed
  - Essam H Ibrahim
  - Mohamed A Fahmy
  - Amr Elkelish
  - Synan F AbuQamar
  - Khaled A El-Tarabily
- PubMed: 41953220
- DOI: 10.3389/fimmu.2025.1713426
10 Insights on
- Improved Immune Modulation
- Low evidence
This review aims to critically integrate historical foundations, dosage strategies, mechanisms of action, therapeutic applications, and potential risks associated with probiotics.
Effect
Beneficial
Effect size
Moderate
Overview of the immunomodulatory role of bacterial probiotic-derived peptidoglycan: from molecular insights to therapeutic application.
- 2026-02-26
- Review
- Frontiers in microbiology 17
- - Omer Qutaiba B Allela
  - Abdulkareem Shareef
  - Hayder Naji Sameer
  - Ahmed Yaseen
  - Zainab H Athab
  - Mohaned Adil
- PubMed: 41834851
- DOI: 10.3389/fmicb.2026.1761985
8 Insights on
- Improved Immune Modulation
- Low evidence
Probiotics are well recognized for their ability to modulate host immune responses; however, growing evidence indicates that many of their beneficial effects are mediated by structural components rather than by viable microorganisms. Among these components, probiotic-derived peptidoglycan has emerged as a key immunologically active molecule with a critical role in regulating both innate and adaptive immunity.
Effect
Beneficial
Effect size
Moderate
Probiotic-derived postbiotics: a perspective on next-generation therapeutics.
- 2025-07-17
- Review
- Frontiers in nutrition 12
- - Veilumuthu Pattapulavar
  - Sathiyabama Ramanujam
  - Bhagyashree Kini
  - John Godwin Christopher
- PubMed: 40747333
- DOI: 10.3389/fnut.2025.1624539
7 Insights on
- Improved Immune Modulation
- Low evidence
We focus on key classes of postbiotics including exopolysaccharides, cell-free supernatants, short-chain fatty acids, and bacteriocins, summarizing their reported immunomodulatory, antimicrobial, antioxidant, and anti-cancer properties.
Effect
Beneficial
Effect size
Moderate

Bifidobacterium plantarum and Improved Immune Modulation

Probiotics and human health: biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - a comprehensive review.

Overview of the immunomodulatory role of bacterial probiotic-derived peptidoglycan: from molecular insights to therapeutic application.

Probiotic-derived postbiotics: a perspective on next-generation therapeutics.