Bifidobacterium plantarum and Improved Immune Modulation

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 review studies, all reported beneficial moderate-sized effects of Bifidobacterium plantarum on immune modulation. However, these are all narrative reviews without original clinical data, and no statistically significant findings were reported. No specific dose range, duration, or population was consistently identified.

Caveats: All three studies are narrative reviews, not original clinical trials; no direct evidence from RCTs or controlled studies. No statistically significant findings were reported, and no dose, duration, or population details were provided. The evidence is limited to theoretical and mechanistic discussions.

Generated May 11, 2026

3 of 3 papers

Probiotics and human health: biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - a comprehensive review.
- 2026-03-24
- Review
- Frontiers in immunology 16
- - Mohamed T El-Saadony
  - Ahmed M Saad
  - Mahmoud Sitohy
  - Samar Sami Alkafaas
  - Mthokozisi Dladla
  - Soumya Ghosh
  - Dina Mostafa Mohammed
  - Essam H Ibrahim
  - Mohamed A Fahmy
  - Amr Elkelish
  - Synan F AbuQamar
  - Khaled A El-Tarabily
- PubMed: 41953220
- DOI: 10.3389/fimmu.2025.1713426
10 Insights on
- Improved Immune Modulation
- Low evidence
This review aims to critically integrate historical foundations, dosage strategies, mechanisms of action, therapeutic applications, and potential risks associated with probiotics.
Effect
Beneficial
Effect size
Moderate
Overview of the immunomodulatory role of bacterial probiotic-derived peptidoglycan: from molecular insights to therapeutic application.
- 2026-02-26
- Review
- Frontiers in microbiology 17
- - Omer Qutaiba B Allela
  - Abdulkareem Shareef
  - Hayder Naji Sameer
  - Ahmed Yaseen
  - Zainab H Athab
  - Mohaned Adil
- PubMed: 41834851
- DOI: 10.3389/fmicb.2026.1761985
8 Insights on
- Improved Immune Modulation
- Low evidence
Probiotics are well recognized for their ability to modulate host immune responses; however, growing evidence indicates that many of their beneficial effects are mediated by structural components rather than by viable microorganisms. Among these components, probiotic-derived peptidoglycan has emerged as a key immunologically active molecule with a critical role in regulating both innate and adaptive immunity.
Effect
Beneficial
Effect size
Moderate
Probiotic-derived postbiotics: a perspective on next-generation therapeutics.
- 2025-07-17
- Review
- Frontiers in nutrition 12
- - Veilumuthu Pattapulavar
  - Sathiyabama Ramanujam
  - Bhagyashree Kini
  - John Godwin Christopher
- PubMed: 40747333
- DOI: 10.3389/fnut.2025.1624539
7 Insights on
- Improved Immune Modulation
- Low evidence
We focus on key classes of postbiotics including exopolysaccharides, cell-free supernatants, short-chain fatty acids, and bacteriocins, summarizing their reported immunomodulatory, antimicrobial, antioxidant, and anti-cancer properties.
Effect
Beneficial
Effect size
Moderate

Bifidobacterium plantarum and Improved Immune Modulation

Probiotics and human health: biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - a comprehensive review.

Overview of the immunomodulatory role of bacterial probiotic-derived peptidoglycan: from molecular insights to therapeutic application.

Probiotic-derived postbiotics: a perspective on next-generation therapeutics.