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Evidence-Based Supplement Research
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Lactobacillus salivarius UCC118 and Improved Immune Modulation

Research synthesisLow evidenceSmall effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 review papers, all reported beneficial effects for improved immune modulation associated with Lactobacillus salivarius UCC118, demonstrating a predominant small effect size. The evidence base consists entirely of review articles, and specific dosing parameters, study populations, forms, and durations were not consistently reported or extracted from the data.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests.

Generated Jul 12, 2026
3 of 3 papers
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