Lactobacillus salivarius UCC118 and Improved Immune Modulation

Research synthesisVery low evidenceSmall effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across all 3 studies (all reviews), beneficial effects of Lactobacillus salivarius UCC118 or its derivatives on immune modulation were reported. The predominant effect size was small. No specific dose, form, or population data were available from these studies.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. All studies are narrative reviews, not interventional trials, and none reported statistical significance. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed).

Generated May 12, 2026

3 of 3 papers

Paraprobiotics and Postbiotics of Probiotic Lactobacilli, Their Positive Effects on the Host and Action Mechanisms: A Review.
- 2020-10-22
- Review
- Frontiers in nutrition 7
- - Tsegay Teame
  - Anran Wang
  - Mingxu Xie
  - Zhen Zhang
  - Yalin Yang
  - Qianwen Ding
  - Chenchen Gao
  - Rolf Erik Olsen
  - Chao Ran
  - Zhigang Zhou
- PubMed: 33195367
- DOI: 10.3389/fnut.2020.570344
4 Insights on
- Improved Immune Modulation
- Moderate evidence
- Highly Cited
Paraprobiotics and postbiotics produced from Lactobacilli consist of a wide range of molecules... which mediate positive effect on the host, such as immunomodulatory... effects.
Effect
Beneficial
Effect size
Small
Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations.
- 2020-09-02
- Review
- FEMS microbiology reviews 45(1)
- - Samira Soltani
  - Riadh Hammami
  - Paul D Cotter
  - Sylvie Rebuffat
  - Laila Ben Said
  - Hélène Gaudreau
  - François Bédard
  - Eric Biron
  - Djamel Drider
  - Ismail Fliss
- PubMed: 32876664
- DOI: 10.1093/femsre/fuaa039
3 Insights on
- Improved Immune Modulation
- Moderate evidence
- Highly Cited
These strains can also modulate the host immune response, suggesting potential health benefits beyond direct antimicrobial activity.
Effect
Beneficial
Effect size
Small
Lactobacilli-Derived Microbe-Associated Molecular Patterns (MAMPs) in Host Immune Modulation.
- 2025-11-17
- Review
- Biomolecules 15(11)
- - Salvatore Furnari
  - Ruben Ciantia
  - Adriana Garozzo
  - Pio Maria Furneri
  - Virginia Fuochi
- PubMed: 41301527
- DOI: 10.3390/biom15111609
4 Insights on
- Improved Immune Modulation
- Low evidence
Lactobacilli-derived MAMPs exhibit dual immunomodulatory effects: they can enhance pro-inflammatory responses... while enhancing regulatory pathways via IL-10 and regulatory T-cell (Tregs) induction in anti-inflammatory settings.
Effect
Beneficial
Effect size
Small

Lactobacillus salivarius UCC118 and Improved Immune Modulation

Paraprobiotics and Postbiotics of Probiotic Lactobacilli, Their Positive Effects on the Host and Action Mechanisms: A Review.

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations.

Lactobacilli-Derived Microbe-Associated Molecular Patterns (MAMPs) in Host Immune Modulation.