Paraprobiotics and Postbiotics of Probiotic Lactobacilli, Their Positive Effects on the Host and Action Mechanisms: A Review.
- 2020-10-22
- Frontiers in nutrition 7
- Tsegay Teame
- Anran Wang
- Mingxu Xie
- Zhen Zhang
- Yalin Yang
- Qianwen Ding
- Chenchen Gao
- Rolf Erik Olsen
- Chao Ran
- Zhigang Zhou
- PubMed: 33195367
- DOI: 10.3389/fnut.2020.570344
Study Design
- Type
- Review
- Methods
- We systematically summarize the paraprobiotics and postbiotics derived from Lactobacilli and their beneficial functions.
- Highly Cited
Lactobacilli comprise an important group of probiotics for both human and animals. The emerging concern regarding safety problems associated with live microbial cells is enhancing the interest in using cell components and metabolites derived from probiotic strains. Here, we define cell structural components and metabolites of probiotic bacteria as paraprobiotics and postbiotics, respectively. Paraprobiotics and postbiotics produced from Lactobacilli consist of a wide range of molecules including peptidoglycans, surface proteins, cell wall polysaccharides, secreted proteins, bacteriocins, and organic acids, which mediate positive effect on the host, such as immunomodulatory, anti-tumor, antimicrobial, and barrier-preservation effects. In this review, we systematically summarize the paraprobiotics and postbiotics derived from Lactobacilli and their beneficial functions. We also discuss the mechanisms underlying their beneficial effects on the host, and their interaction with the host cells. This review may boost our understanding on the benefits and molecular mechanisms associated with paraprobiotics and probiotics from Lactobacilli, which may promote their applications in humans and animals.
Research Insights
Paraprobiotics and postbiotics produced from Lactobacilli consist of a wide range of molecules including... which mediate positive effect on the host, such as... barrier-preservation effects.
- Effect
- Beneficial
- Effect size
- Small
Lactobacilli comprise an important group of probiotics... [their components] mediate positive effect on the host, such as immunomodulatory... effects.
- Effect
- Beneficial
- Effect size
- Moderate
Paraprobiotics and postbiotics produced from Lactobacilli consist of a wide range of molecules... which mediate positive effect on the host, such as immunomodulatory... effects.
- Effect
- Beneficial
- Effect size
- Small
Paraprobiotics and postbiotics produced from Lactobacilli consist of a wide range of molecules ... which mediate positive effect on the host, such as immunomodulatory... effects.
- Effect
- Beneficial
- Effect size
- Moderate