Lactobacillus acidophilus L-92 and Improved Immune Modulation

Research synthesisLow evidenceModerate effect5 studies · 5 beneficial · 0 neutral · 0 harmful

Across 5 studies, all reported beneficial effects of Lactobacillus acidophilus L-92 on immune modulation, with a predominant moderate effect size. The evidence includes a statistically significant finding of enhanced phagocytic activity and IFN-γ production in human immune cells, as well as anti-allergic effects via increased IL-12, IFN-γ, and IL-10 and decreased IL-4 from splenocytes. Most studies were reviews focusing on animal populations or general probiotic mechanisms, and doses and study durations were not reported.

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 5 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Most studies are reviews with limited primary data; only one study reported a statistically significant finding.

Generated Jul 11, 2026

5 of 5 papers

Metagenomic evaluation, antimicrobial activities, and immune stimulation of probiotics from dietary supplements and dairy products.
- 2025-04-04
- Scientific reports 15(1)
- - Piyaorn Chornchoem
  - Sarunporn Tandhavanant
  - Natnaree Saiprom
  - Anucha Preechanukul
  - Nartthawee Thongchompoo
  - Insee Sensorn
  - Wasun Chantratita
  - Narisara Chantratita
- PubMed: 40185827
- DOI: 10.1038/s41598-025-95664-w
5 Insights on
- Improved Immune Modulation
- Low evidence
- Rigorous Journal
some strains of Lactobacillus spp. significantly enhanced phagocytic activity in monocytes and increased IFN-γ production in NK cells
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.
- 2025-12-12
- Review
- Veterinary sciences 12(12)
- - Sahdeo Prasad
  - Bhaumik Patel
  - Prafulla Kumar
  - Rajiv Lall
- PubMed: 41472171
- DOI: 10.3390/vetsci12121191
13 Insights on
- Improved Immune Modulation
- Low evidence
Postbiotics also inhibit pro-inflammatory molecules like TNF-α and IL-6, while enhancing the anti-inflammatory cytokine IL-10, promoting the maturation and function of immune cells, and increasing secretory IgA production.
Effect
Beneficial
Effect size
Moderate
Fruit and Vegetable Juices as Functional Carriers for Probiotic Delivery: Microbiological, Nutritional, and Sensory Perspectives.
- 2025-05-30
- Review
- Microorganisms 13(6)
- - Renata Žvirdauskienė
  - Vesta Jonikė
  - Loreta Bašinskienė
  - Dalia Čižeikienė
- PubMed: 40572160
- DOI: 10.3390/microorganisms13061272
3 Insights on
- Improved Immune Modulation
- Low evidence
Lactobacillus acidophilus L-92 is reported to have various immune regulatory and anti-allergic effects
Effect
Beneficial
Effect size
Moderate
The Role of Probiotics in Enhancing Animal Health: Mechanisms, Benefits, and Applications in Livestock and Companion Animals.
- 2025-10-15
- Review
- Animals : an open access journal from MDPI 15(20)
- - Sorin Marian Mârza
  - Camelia Munteanu
  - Ionel Papuc
  - Lăcătuş Radu
  - Robert Cristian Purdoiu
- PubMed: 41153915
- DOI: 10.3390/ani15202986
4 Insights on
- Improved Immune Modulation
- Low evidence
Lactobacillus acidophilus L-92 is associated with immunomodulatory effects that may support host defense and balance immune responses.
Effect
Beneficial
Effect size
Small
Increases in GroES and GroEL from Lactobacillus acidophilus L-92 in response to a decrease in medium pH, and changes in cytokine release from splenocytes: Transcriptome and proteome analyses.
- 2012-07
- Journal of Bioscience and Bioengineering 114(1)
- - Rumiko Kuwana
  - N. Yamamoto
- PubMed: 22417456
- DOI: 10.1016/j.jbiosc.2012.02.010
7 Insights on
- Improved Immune Modulation
- Low evidence
To study the anti-allergy effects of probiotic Lactobacillus acidophilus L-92 (L-92)... the release of IL-12, IFN-γ and IL-10 was increased but IL-4 release was decreased from splenocytes.
Effect
Beneficial
Effect size
Moderate

Lactobacillus acidophilus L-92 and Improved Immune Modulation

Metagenomic evaluation, antimicrobial activities, and immune stimulation of probiotics from dietary supplements and dairy products.

Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.

Fruit and Vegetable Juices as Functional Carriers for Probiotic Delivery: Microbiological, Nutritional, and Sensory Perspectives.

The Role of Probiotics in Enhancing Animal Health: Mechanisms, Benefits, and Applications in Livestock and Companion Animals.

Increases in GroES and GroEL from Lactobacillus acidophilus L-92 in response to a decrease in medium pH, and changes in cytokine release from splenocytes: Transcriptome and proteome analyses.