Best Supplements for Reduced Insulin Levels
Ranked by research evidence. Compare 40 supplements across 50 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence3 studies
Across 3 meta-analyses, 2 reported beneficial moderate-to-large effects of vitamin D supplementation on reducing insulin levels in patients with diabetes/prediabetes and women with PCOS, while one large meta-analysis in overweight/obese children found no significant effect. The predominant effect size among beneficial studies was mixed (moderate to large). No dose or form data were consistently reported across studies.
Product matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208) - Low evidence3 studies
Across 3 studies on Lactobacillus salivarius UCC118 and reduced insulin levels, 2 reported beneficial effects (moderate in size) while 1 found neutral effects. The beneficial evidence comes from meta-analyses/reviews of pregnant women with gestational diabetes, while the single neutral result comes from an RCT in the same population. Effect sizes were moderate, though the only trial with a neutral finding reported a small effect. The evidence base is too small to determine a specific effective dose range or consistent study duration.
- ModerateVitamin DAcross 3 meta-analyses, 2 reported beneficial moderate-to-large effects of vitamin D supplementation on reducing insulin levels in patients with diabetes/prediabetes and women with PCOS, while one large meta-analysis in overweight/obese children found no significant effect. The predominant effect size among beneficial studies was mixed (moderate to large). No dose or form data were consistently reported across studies.2 beneficial1 neutral3 studies
- LowLactobacillus salivarius UCC118Across 3 studies on Lactobacillus salivarius UCC118 and reduced insulin levels, 2 reported beneficial effects (moderate in size) while 1 found neutral effects. The beneficial evidence comes from meta-analyses/reviews of pregnant women with gestational diabetes, while the single neutral result comes from an RCT in the same population. Effect sizes were moderate, though the only trial with a neutral finding reported a small effect. The evidence base is too small to determine a specific effective dose range or consistent study duration.2 beneficial1 neutral3 studies