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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin D and Reduced Insulin Levels

Research synthesisLow evidenceModerate effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial effects of vitamin D supplementation on reducing insulin levels, with effect sizes ranging from moderate to large, while 1 neutral study showed no significant improvement. The evidence is dominated by meta-analyses in clinical populations (patients with diabetes/prediabetes and women with PCOS), with the strongest effects observed in the PCOS population. The evidence base is small, and no consistent dose or duration data were reported.

  • Studied populations: patients with diabetes and prediabetes; reproductive-age women with polycystic ovary syndrome (PCOS)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The neutral study (a meta-analysis in obese/overweight children) did not find significant benefit, suggesting population-specific effects. Doses and study durations were not consistently reported, limiting generalizability.

Generated Jul 15, 2026
3 of 3 papers
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