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Evidence-Based Supplement Research
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Lactobacillus salivarius UCC118 and Reduced Insulin Levels

Research synthesisLow evidenceModerate effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies on Lactobacillus salivarius UCC118 and reduced insulin levels, 2 reported beneficial effects (moderate in size) while 1 found neutral effects. The beneficial evidence comes from meta-analyses/reviews of pregnant women with gestational diabetes, while the single neutral result comes from an RCT in the same population. Effect sizes were moderate, though the only trial with a neutral finding reported a small effect. The evidence base is too small to determine a specific effective dose range or consistent study duration.

  • Studied populations: pregnant women with gestational diabetes or impaired glucose tolerance

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The only RCT (evidence score 7) found neutral results, while the two meta-analyses/reviews (scores 5 and 3) showed benefit, raising the possibility that higher-quality individual trials may not replicate the meta-analytic findings. Only 1 of 3 studies reported a statistically significant result.

Generated Jun 18, 2026
3 of 3 papers
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