Best Supplements for Reduced Interleukin-6 Levels
Ranked by research evidence. Compare 50 supplements across 57 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence3 studies
Across 3 studies, 2 reported beneficial moderate-sized effects of turmeric/curcumin on reducing interleukin-6 levels, while 1 reported a neutral small effect. Two studies reached statistical significance. Studies primarily involved clinical populations (chronic lower back pain, metabolic syndrome) and used doses around 300 mg to 2 g daily over a median duration of 66 days, suggesting effects typically observed at 6-12 weeks.
Dose: 300 mg to 2 g daily - Low evidence3 studies
Across 3 studies, 2 reported beneficial small-sized effects of vitamin D on reducing interleukin-6 (IL-6) levels, while 1 reported neutral findings. The only study with a statistically significant benefit was an RCT in overweight/obese adults with low-grade inflammation using a low dose of 200 IU daily over 56 days. The evidence is preliminary and limited by the small number of studies and mixed results.
Dose: 200 IU dailyProduct matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208)
- LowTurmericAcross 3 studies, 2 reported beneficial moderate-sized effects of turmeric/curcumin on reducing interleukin-6 levels, while 1 reported a neutral small effect. Two studies reached statistical significance. Studies primarily involved clinical populations (chronic lower back pain, metabolic syndrome) and used doses around 300 mg to 2 g daily over a median duration of 66 days, suggesting effects typically observed at 6-12 weeks. · Dose: 300 mg to 2 g daily2 beneficial1 neutral3 studies
- LowVitamin DAcross 3 studies, 2 reported beneficial small-sized effects of vitamin D on reducing interleukin-6 (IL-6) levels, while 1 reported neutral findings. The only study with a statistically significant benefit was an RCT in overweight/obese adults with low-grade inflammation using a low dose of 200 IU daily over 56 days. The evidence is preliminary and limited by the small number of studies and mixed results. · Dose: 200 IU daily2 beneficial1 neutral3 studies