Best Supplements for Reduced Interleukin-6 Levels
Ranked by research evidence. Compare 90 supplements across 137 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence8 studies
Vitamin D supplementation shows moderate evidence for reducing IL-6 levels. Among 8 studies, 5 reported beneficial effects with a predominant moderate effect size, while 3 found no significant change. The median study duration was 56 days, and most studies used daily doses between 200 and 5000 IU in clinical populations such as colorectal cancer patients, overweight/obese adults, and those with low-grade inflammation.
Product matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208) - Moderate evidence7 studies
Across 7 studies, 4 reported beneficial effects of vitamin C on reducing interleukin-6 levels, with effect sizes ranging from small to moderate, while 3 found neutral effects. The median study duration was 28 days, though effects were observed in both acute (1-day) and longer-term (84-day) settings. Most studied populations were clinical (e.g., cardiac surgery, septic shock, hemodialysis patients), and doses ranged from 250 mg to 1000 mg/day.
Dose: 250-1000 mg/day - Moderate evidence4 studies
Across all 4 studies, black cumin (Nigella sativa) supplementation consistently shows moderate beneficial effects on reducing interleukin-6 (IL-6) levels. All 4 studies report statistically significant reductions, with a median study duration of 32 days (approximately 4–8 weeks). The most-studied dose range is 2000–4600 mg/day, and effects are observed in populations with metabolic syndrome, overweight/obesity, and related inflammatory conditions.
Dose: 2000–4600 mg/day
- ModerateVitamin DVitamin D supplementation shows moderate evidence for reducing IL-6 levels. Among 8 studies, 5 reported beneficial effects with a predominant moderate effect size, while 3 found no significant change. The median study duration was 56 days, and most studies used daily doses between 200 and 5000 IU in clinical populations such as colorectal cancer patients, overweight/obese adults, and those with low-grade inflammation.5 beneficial3 neutral8 studies
- ModerateVitamin CAcross 7 studies, 4 reported beneficial effects of vitamin C on reducing interleukin-6 levels, with effect sizes ranging from small to moderate, while 3 found neutral effects. The median study duration was 28 days, though effects were observed in both acute (1-day) and longer-term (84-day) settings. Most studied populations were clinical (e.g., cardiac surgery, septic shock, hemodialysis patients), and doses ranged from 250 mg to 1000 mg/day. · Dose: 250-1000 mg/day4 beneficial3 neutral7 studies
- ModerateBlack CuminAcross all 4 studies, black cumin (Nigella sativa) supplementation consistently shows moderate beneficial effects on reducing interleukin-6 (IL-6) levels. All 4 studies report statistically significant reductions, with a median study duration of 32 days (approximately 4–8 weeks). The most-studied dose range is 2000–4600 mg/day, and effects are observed in populations with metabolic syndrome, overweight/obesity, and related inflammatory conditions. · Dose: 2000–4600 mg/day4 beneficial4 studies
- ModerateCardamomAcross all 3 studies, all reported beneficial effects of cardamom on reducing interleukin-6 levels, with 2 meta-analyses showing small effects and 1 randomized controlled trial showing a moderate effect. Effects were observed in clinical populations including patients with metabolic syndrome and obese women with PCOS, with a single reported dose of 3 g/day over 120 days showing significant reductions. The median study duration was 120 days, suggesting effects typically emerge after several weeks of supplementation. · Dose: 3 g/day3 beneficial3 studies
- LowPropolisAcross 4 studies, 2 reported beneficial effects on interleukin-6 levels, while 2 found no significant effect; the predominant effect size was mixed (small to large). The evidence base includes meta-analyses in clinical populations with type 2 diabetes, but no consistent dose range or duration was reported. Overall, propolis shows mixed evidence for reducing IL-6, with findings varying by study design and population.2 beneficial2 neutral4 studies
- LowTurmericAcross 4 studies, 2 reported beneficial moderate-sized effects on reducing interleukin-6 (IL-6) levels, while 2 found neutral results with small or no effect. The predominant effect direction is beneficial, but effect sizes were mixed (moderate for beneficial studies vs. small for neutral studies). The most studied population was clinical (e.g., chronic lower back pain, knee osteoarthritis, metabolic syndrome), with a median study duration of 84 days, suggesting effects are typically observed at 8-12 weeks.2 beneficial2 neutral4 studies
- LowWhey ProteinAcross 4 studies, 2 reported beneficial small-sized effects on reducing interleukin-6 levels, while 2 found neutral effects. The median study duration was 73 days, suggesting effects may require 8–12 weeks. The most-studied dose range is 20–25 g/day in older clinical populations, particularly those with sarcopenia or frailty and hemodialysis patients. · Dose: 20–25 g/day2 beneficial2 neutral4 studies