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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin D and Reduced Interleukin-6 Levels

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial small-sized effects of vitamin D on reducing interleukin-6 (IL-6) levels, while 1 reported neutral findings. The only study with a statistically significant benefit was an RCT in overweight/obese adults with low-grade inflammation using a low dose of 200 IU daily over 56 days. The evidence is preliminary and limited by the small number of studies and mixed results.

  • Effective dose range: 200 IU daily
  • Studied populations: overweight/obese adults with low-grade inflammation; patients with plaque psoriasis (adjunctive therapy)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. One beneficial study used a combined intervention (vitamin D with probiotics and omega-3s), complicating attribution of the effect to vitamin D alone.

Generated May 24, 2026
Doses used in studies
  • IU/day: 200 (median 200, IQR 200–200) — 1 study
Time to effect
Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 3 studies
Safety in these studies
3 of 3 papers
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