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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced Interleukin-6 Levels

Safety in these studies

Overall tolerabilityNo significant differencerisk ratio 1.02, 95% CI 0.94-1.10
Adverse events were comparable across interventions (risk ratio 1.02, 95% CI 0.94-1.10).
from: Effectiveness and safety of dietary supplements in the adjunctive treatment of psoriasis:

2 of 2 papersPopulation:

Effectiveness and safety of dietary supplements in the adjunctive treatment of psoriasis: a systematic review and network meta-analysis.
- 2025-12-11
- Systematic Review · n = 463
- Frontiers in nutrition 12
- - Danping Chen
  - Jie Yang
  - Wenwen Yang
  - Xinying Liu
  - Zhihong Li
- PubMed: 41459063
- DOI: 10.3389/fnut.2025.1718828
5 Insights on
- Reduced Interleukin-6 Levels
- High evidence
- Clinical
vitamin D + NB-UVB most consistently lowered IL-6/IL-17/IL-23
Effect
Beneficial
Effect size
Small
Significant
No
Effects of Vitamin D3 Supplementation on Inflammatory Markers in Overweight and Obese Children and Adolescents: A Systematic Review.
- 2025-07-20
- Review · n = 294
- Life (Basel, Switzerland) 15(7)
- - Maria Krajewska
  - Ewelina Witkowska-Sędek
- PubMed: 40724644
- DOI: 10.3390/life15071142
4 Insights on
- Reduced Interleukin-6 Levels
- High evidence
- Children
vitamin D3 supplementation did not affect the changes in ... interleukin-6 (IL-6)
Effect
Neutral
Effect size
Small
Significant
No