Black Cumin and Reduced Interleukin-6 Levels

• Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials.

  • 2025-09
  • Meta-Analysis · n = 5,026
  • Pharmacological research 219
  • • Ali Jafari
    • Helia Mardani
    • Amir Hossein Faghfouri
    • Zahra Mirzaei Fashtali
    • Mohtaram Hashemi
    • Matin Abdollahi Yousefabady
    • Reihane Javid
    • Sahar Golabi
    • Bahareh Arghavan
    • Vali Musazadeh
    • Mahshid Naghashpour

  • PubMed: 40714301
  • DOI: 10.1016/j.phrs.2025.107882

  35 Insights on

  • Reduced Interleukin-6 Levels

  • High evidence

  N. sativa supplementation significantly improved ... interleukin-6 (IL-6)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  200 to 4600 mg/day

• A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women.

  • 2024-01-05
  • RCT
  • BMC complementary medicine and therapies 24(1)
  • • Elham Razmpoosh
    • Sara Safi
    • Mahta Mazaheri
    • Saman Khalesi
    • Majid Nazari
    • Parvin Mirmiran
    • Azadeh Nadjarzadeh

  • PubMed: 38178093
  • DOI: 10.1186/s12906-023-04226-y

  6 Insights on

  • Reduced Interleukin-6 Levels

  • High evidence
  • Clinical

  Significant reductions with large effect sizes were observed in the gene expression and serum levels of IL-6(d=-1.8, d=-0.78, respectively; P < 0.01)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  2000 mg/day