Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

2024-05
Current pharmaceutical biotechnology 25(7)
- Hossein Hosseini
- Farideh Ghavidel
- Mahdieh Aliyari
- Seyed Isaac Hashemy
- Tannaz Jamialahmadi
- Amirhossein Sahebkar

PubMed: 37859312
DOI: 10.2174/0113892010266109230928000134

Study Design

Type: Meta-Analysis
Sample size: n = 1,033
Population: 1033 participants diagnosed with metabolic syndrome and its associated conditions
Methods: Meta-analysis of 16 RCTs; search conducted on Web of Science, Scopus, PubMed, and EMBASE until August 2023

Background

Several studies have shown that the intake of N. sativa has a beneficial effect on metabolic syndrome and related disorders. In this meta-analysis, our primary objective was to assess the impact of Nigella sativa consumption on inflammation and oxidative stress biomarkers among individuals diagnosed with metabolic syndrome and its associated conditions.

Methods

Our search was conducted on prominent online databases such as Web of Science, Scopus, PubMed, and EMBASE, utilizing relevant keywords until August 2023.

Results

This meta-analysis was performed on 16 RCTs comprising 1033 participants. Our results showed that intake of Nigella sativa significantly decreased CRP (SMD: -0.60; (95% CI: from -0.96 to -0.23); P = 0.00), TNF-α (SMD: -0.53; (95% CI: from -0.74 to -0.53); P = 0.00); IL-6 (SMD: -0.54 ; (95% CI: from -1.01 to -0.07); P = 0.02), and MDA: (SMD: -1.28; (95% CI: from -2.11 to -0.46); P = 0.00) levels. In addition, SOD: (SMD: 1.35; (95% CI, from 0.77 to 1.93); P = 0.00) and TAC (SMD: 2.82; (95% CI, from 0.55 to 5.084); P = 0.01) levels significantly increased in the intervention group compared to the placebo group.

Conclusion

Our results showed that THE consumption of N. sativa could be associated with improved oxidative stress and inflammation in patients with metabolic syndrome and related disorders.

Research Insights

Black Cumin→Increased Antioxidant Enzyme Levels
SOD: (SMD: 1.35; (95% CI, from 0.77 to 1.93); P = 0.00) levels significantly increased
Effect
Beneficial
Effect size
Large
Black Cumin→Increased Total Serum Antioxidant Capacity
TAC (SMD: 2.82; (95% CI, from 0.55 to 5.084); P = 0.01) levels significantly increased
Effect
Beneficial
Effect size
Large
Black Cumin→Reduced C-Reactive Protein Levels
intake of Nigella sativa significantly decreased CRP (SMD: -0.60; (95% CI: from -0.96 to -0.23); P = 0.00)
Effect
Beneficial
Effect size
Moderate
Black Cumin→Reduced Interleukin-6 Levels
intake of Nigella sativa significantly decreased IL-6 (SMD: -0.54 ; (95% CI: from -1.01 to -0.07); P = 0.02)
Effect
Beneficial
Effect size
Moderate
Black Cumin→Reduced Malondialdehyde
intake of Nigella sativa significantly decreased MDA: (SMD: -1.28; (95% CI: from -2.11 to -0.46); P = 0.00)
Effect
Beneficial
Effect size
Large
Black Cumin→Reduced Tumor Necrosis Factor Alpha
intake of Nigella sativa significantly decreased TNF-α (SMD: -0.53; (95% CI: from -0.74 to -0.53); P = 0.00)
Effect
Beneficial
Effect size
Moderate