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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Black Cumin and Reduced C-Reactive Protein Levels

Research synthesisModerate evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 meta-analyses, all 3 reported statistically significant moderate-sized beneficial effects of Nigella sativa (black cumin) supplementation on reducing C-reactive protein (CRP) levels. The predominant effect size is moderate. The largest study (n=5,026) reported a dose range of 200–4600 mg/day over 7 days. Evidence is strongest for populations with metabolic syndrome and related conditions.

  • Effective dose range: 200 to 4600 mg/day
  • Studied populations: people with metabolic syndrome and related conditions

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Study duration data is limited (only 1 of 3 studies reported duration, at 7 days), so long-term effects are unclear.

Generated Jun 4, 2026
Doses used in studies
  • mg/day: 200–4,600 (median 2,400, IQR 200–4,600) — 1 study
Time to effect
Median: 7 days · IQR 7 days–7 days · Range 7 days–7 days — Reported in 1 of 3 studies
3 of 3 papers
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