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Alleviating effects of Nigella sativa supplements on biomarkers of inflammation and oxidative stress: Results from an umbrella meta-analysis.

  • 2025-01
  • Prostaglandins & other lipid mediators 176
    • Xinyu Lan
    • Yongliang Xia

Study Design

Type
Meta-Analysis
Methods
Systematic search of Embase, Web of Science, Scopus, PubMed, and Google Scholar for papers indexed before February 2023; pooled analysis using random-effects model; GRADE assessment.
Several meta-analyses have examined the effect of Nigella sativa (N. Sativa) supplementation on inflammatory and oxidative markers, with conflicting results. So, the current study evaluated the effect of N. Sativa on some oxidative and inflammatory parameters. The Embase, Web of Science, Scopus, PubMed databases, and Google Scholar were systemically searched to identify papers indexed before February 2023. The pooled results were calculated with the use of a random-effects model to evaluate the effects of N. Sativa on inflammatory and oxidative markers. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the certainty of evidence. Overall, seven meta-analyses were included in the study. N. Sativa supplementation significantly decreased serum C-reactive protein (CRP) (ES = -0.42; 95 % CI: -0.58, -0.25, p < 0.001), tumor necrosis factor-alpha (TNF-α) (ES= -1.27; 95 % CI: -2.29, -0.25; p = 0.015), and malondialdehyde (MDA) (ES = -0.67; 95 % CI: -0.97, -0.36, p < 0.001) levels, and significantly improved total antioxidant capacity (TAC) (ES = 0.34; 95 % CI: 0.20, 0.47, p < 0.001) and superoxide dismutase (SOD) (ES = 50.66; 95 % CI: 34.15, 67.18, p < 0.001) levels. N. Sativa supplementation had beneficial effects on CRP, TNF-α, MDA, SOD, and TAC. Thus, N. Sativa can be recommended as an adjuvant anti-inflammatory and anti-oxidant agent.

Research Insights

  • Black Cumin→Improved Antioxidant Capacity

    N. Sativa supplementation significantly improved total antioxidant capacity (TAC) (ES = 0.34; 95 % CI: 0.20, 0.47, p < 0.001)

    Effect
    Beneficial
    Effect size
    Moderate
  • Black Cumin→Improved Superoxide Dismutase Level

    N. Sativa supplementation significantly improved ... superoxide dismutase (SOD) (ES = 50.66; 95 % CI: 34.15, 67.18, p < 0.001)

    Effect
    Beneficial
    Effect size
    Large
  • Black Cumin→Reduced C-Reactive Protein Levels

    N. Sativa supplementation significantly decreased serum C-reactive protein (CRP) (ES = -0.42; 95 % CI: -0.58, -0.25, p < 0.001)

    Effect
    Beneficial
    Effect size
    Moderate
  • Black Cumin→Reduced Malondialdehyde

    N. Sativa supplementation significantly decreased ... malondialdehyde (MDA) (ES = -0.67; 95 % CI: -0.97, -0.36, p < 0.001)

    Effect
    Beneficial
    Effect size
    Moderate
  • Black Cumin→Reduced Tumor Necrosis Factor Alpha

    N. Sativa supplementation significantly decreased ... tumor necrosis factor-alpha (TNF-α) (ES= -1.27; 95 % CI: -2.29, -0.25; p = 0.015)

    Effect
    Beneficial
    Effect size
    Large
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