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Evidence-Based Supplement Research
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Black Cumin and Reduced Malondialdehyde

Research synthesisModerate evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

All 3 available meta-analyses report significant beneficial effects of Nigella sativa (black cumin) supplementation on reducing malondialdehyde (MDA), a marker of oxidative stress. Effect sizes are predominantly moderate (two studies) to large (one study). Doses ranged from 200 to 4600 mg/day in one study, but form was not specified; effects were observed in both general adult populations and individuals with metabolic syndrome and related disorders.

  • Studied populations: general adult population; patients with metabolic syndrome and related disorders

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Additionally, the median study duration was only 7 days (from one study), which is short for assessing changes in oxidative stress markers; longer-term effects remain uncertain. Doses varied widely (200–4600 mg/day) and form was not specified, limiting practical guidance.

Generated Jun 4, 2026
Doses used in studies
  • mg/day: 200–4,600 (median 2,400, IQR 200–4,600) — 1 study
Time to effect
Median: 7 days · IQR 7 days–7 days · Range 7 days–7 days — Reported in 1 of 3 studies
3 of 3 papers
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