Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Black Cumin and Reduced Malondialdehyde

Research synthesisModerate evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 meta-analyses, all 3 reported beneficial effects of black cumin (Nigella sativa) supplementation on reducing malondialdehyde (MDA), with effect sizes ranging from moderate to large (predominantly moderate). The evidence is derived from meta-analyses including up to 82 randomized controlled trials, with doses varying widely (200–4600 mg/day) and no clear form convergence.

  • Studied populations: General adult population and individuals with metabolic syndrome and related conditions

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias. Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The reported dose range is very wide (200–4600 mg/day), and only one study provided specific dose information, making it difficult to recommend a precise effective dose.

Generated Jul 4, 2026
Doses used in studies
  • mg/day: 200–4,600 (median 2,400, IQR 200–4,600) — 1 study
Time to effect
Median: 7 days · IQR 7 days–7 days · Range 7 days–7 days — Reported in 1 of 3 studies
3 of 3 papers
Back to top