Best Supplements for Reduced Malondialdehyde
Ranked by research evidence. Compare 25 supplements across 35 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence3 studies
Across 3 meta-analyses, all 3 reported beneficial effects of black cumin (Nigella sativa) supplementation on reducing malondialdehyde (MDA), with effect sizes ranging from moderate to large (predominantly moderate). The evidence is derived from meta-analyses including up to 82 randomized controlled trials, with doses varying widely (200–4600 mg/day) and no clear form convergence.
- Low evidence4 studies
Across 4 studies, 2 reported beneficial effects of L-carnitine on reducing malondialdehyde (MDA), with the predominant effect size being small. The two beneficial studies included a large meta-analysis (n=3255, p=0.001) and a small RCT in women with migraine; the two neutral studies were smaller RCTs in critically ill septic and obese female patients. The median study duration was 56 days (8 weeks), and doses ranged from 500 mg/day to 3 g/day, primarily in clinical adult populations.
- ModerateBlack CuminAcross 3 meta-analyses, all 3 reported beneficial effects of black cumin (Nigella sativa) supplementation on reducing malondialdehyde (MDA), with effect sizes ranging from moderate to large (predominantly moderate). The evidence is derived from meta-analyses including up to 82 randomized controlled trials, with doses varying widely (200–4600 mg/day) and no clear form convergence.3 beneficial3 studies
- LowL-CarnitineAcross 4 studies, 2 reported beneficial effects of L-carnitine on reducing malondialdehyde (MDA), with the predominant effect size being small. The two beneficial studies included a large meta-analysis (n=3255, p=0.001) and a small RCT in women with migraine; the two neutral studies were smaller RCTs in critically ill septic and obese female patients. The median study duration was 56 days (8 weeks), and doses ranged from 500 mg/day to 3 g/day, primarily in clinical adult populations.2 beneficial2 neutral4 studies