Best Supplements for Reduced Malondialdehyde
Ranked by research evidence. Compare 23 supplements across 31 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence3 studies
All 3 available meta-analyses report significant beneficial effects of Nigella sativa (black cumin) supplementation on reducing malondialdehyde (MDA), a marker of oxidative stress. Effect sizes are predominantly moderate (two studies) to large (one study). Doses ranged from 200 to 4600 mg/day in one study, but form was not specified; effects were observed in both general adult populations and individuals with metabolic syndrome and related disorders.
- Low evidence4 studies
Across 4 studies, 2 reported beneficial effects of L-carnitine on reducing malondialdehyde (MDA), while 2 found neutral effects; no harmful effects were observed. The predominant effect size among beneficial studies was small, with a median study duration of 56 days. Evidence is strongest in clinical populations, including women with migraine and adults in a meta-analysis, with doses ranging from 500 mg/day to 3 g/day.
Dose: 500 mg/day to 3 g/day
- ModerateBlack CuminAll 3 available meta-analyses report significant beneficial effects of Nigella sativa (black cumin) supplementation on reducing malondialdehyde (MDA), a marker of oxidative stress. Effect sizes are predominantly moderate (two studies) to large (one study). Doses ranged from 200 to 4600 mg/day in one study, but form was not specified; effects were observed in both general adult populations and individuals with metabolic syndrome and related disorders.3 beneficial3 studies
- LowL-CarnitineAcross 4 studies, 2 reported beneficial effects of L-carnitine on reducing malondialdehyde (MDA), while 2 found neutral effects; no harmful effects were observed. The predominant effect size among beneficial studies was small, with a median study duration of 56 days. Evidence is strongest in clinical populations, including women with migraine and adults in a meta-analysis, with doses ranging from 500 mg/day to 3 g/day. · Dose: 500 mg/day to 3 g/day2 beneficial2 neutral4 studies