Best Supplements for Reduced Abdominal Pain
Ranked by research evidence. Compare 42 supplements across 62 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence11 studies
Across 11 studies, 9 reported beneficial effects of Lactobacillus reuteri DSM 17938 on reducing abdominal pain, with effect sizes ranging from small to moderate. The most commonly studied population was children with functional abdominal pain, and the typical dose used was 10^8 CFU/day. Effects were observed at a median study duration of 7 weeks, though several key trials lasted 8–17 weeks.
Dose: 10^8 CFU/dayProduct matchBioGaia — Kids, Immune Active with L. Reuteri + Vitamin D, Orange· $26.99 · ★4.8 (510) - Moderate evidence3 studies
Across 3 studies, all reported beneficial effects on abdominal pain, with two showing large effect sizes and one moderate. The typical dose was 2 × 10^9 CFU/day (2 billion spores). Evidence primarily in adults with Irritable Bowel Syndrome (IBS) or functional gas and bloating.
Dose: 2 × 10^9 CFU/day (2 billion spores) - Low evidence3 studies
Across 3 randomized controlled trials, Lactobacillus gasseri BNR17 showed moderate beneficial effects on reducing abdominal pain in populations with functional constipation or irritable bowel syndrome (IBS). All 3 studies reported statistically significant improvements, with effect sizes ranging from moderate to large. Doses and study durations were not consistently reported, limiting precise dose-response conclusions.
- ModerateLactobacillus reuteri DSM 17938Across 11 studies, 9 reported beneficial effects of Lactobacillus reuteri DSM 17938 on reducing abdominal pain, with effect sizes ranging from small to moderate. The most commonly studied population was children with functional abdominal pain, and the typical dose used was 10^8 CFU/day. Effects were observed at a median study duration of 7 weeks, though several key trials lasted 8–17 weeks. · Dose: 10^8 CFU/day9 beneficial2 neutral11 studies
- ModerateBacillus coagulans MTCC 5856Across 3 studies, all reported beneficial effects on abdominal pain, with two showing large effect sizes and one moderate. The typical dose was 2 × 10^9 CFU/day (2 billion spores). Evidence primarily in adults with Irritable Bowel Syndrome (IBS) or functional gas and bloating. · Dose: 2 × 10^9 CFU/day (2 billion spores)3 beneficial3 studies
- LowLactobacillus gasseri BNR17Across 3 randomized controlled trials, Lactobacillus gasseri BNR17 showed moderate beneficial effects on reducing abdominal pain in populations with functional constipation or irritable bowel syndrome (IBS). All 3 studies reported statistically significant improvements, with effect sizes ranging from moderate to large. Doses and study durations were not consistently reported, limiting precise dose-response conclusions.3 beneficial3 studies
- Very lowLactobacillus plantarum 299vAcross 3 studies on Lactobacillus plantarum 299v for reduced abdominal pain, 2 reported beneficial effects (moderate to large) and 1 found no significant difference. The evidence is preliminary and mixed — the beneficial studies were a non-interventional observational trial and a review, while the sole randomized controlled trial (n=190) showed a neutral, non-significant effect. · Dose: 1 × 10^10 CFU/day (based on one observational study)2 beneficial1 neutral3 studies