Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.

2023-09-04
Systematic Review · n = 9,253
Nutrients 15(17)
- Peiwei Xie
- Mei Luo
- Xuehong Deng
- Jiahui Fan
- Lishou Xiong

PubMed: 37686889
DOI: 10.3390/nu15173856

Reduced Abdominal Pain

High evidence
Rigorous Journal

Bacillus coagulans MTCC 5856 (SUCRA, 96.9%) and Bacillus coagulans Unique IS2 (SUCRA, 92.6%) were among the most effective probiotics for improving abdominal pain.

Effect: Beneficial
Effect size: Large
Significant: Yes

Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: a double blind randomized placebo controlled pilot clinical study

2015-12
RCT · n = 36
Nutrition Journal 15(1)
- M. Majeed
- K. Nagabhushanam
- Sankaran Natarajan
- A. Sivakumar
- Furqan Ali
- A. Pande
- Shaheen Majeed
- S. K. Karri

PubMed: 26922379
DOI: 10.1186/s12937-016-0140-6

11 Insights on

Reduced Abdominal Pain

High evidence
Highly Cited

There was a significant decrease in the clinical symptoms like bloating, vomiting, diarrhea, abdominal pain and stool frequency in a patient group receiving B. coagulans MTCC 5856 when compared to placebo group (p < 0.01).

Effect: Beneficial
Effect size: Moderate
Significant: Yes
Dose: 2 × 10(9) cfu/day