Best Supplements for Improved Irritable Bowel Syndrome Symptoms
Ranked by research evidence. Compare 32 supplements across 37 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across 4 studies, 3 reported beneficial effects of Lactobacillus plantarum 299v on irritable bowel syndrome symptoms, with effect sizes ranging from moderate to large; 1 study (a meta-analysis) found neutral results. The beneficial studies included a small randomized controlled trial (n=20) showing improvement in 95% of patients vs 15% with placebo (p<0.0001) and a larger observational study (n=221) showing significant symptom reduction. Effects are typically observed over 4–12 weeks, though median study duration was 28 days.
Dose: 1×10^10 CFU/day
32 supplements
- ModerateLactobacillus plantarum 299vAcross 4 studies, 3 reported beneficial effects of Lactobacillus plantarum 299v on irritable bowel syndrome symptoms, with effect sizes ranging from moderate to large; 1 study (a meta-analysis) found neutral results. The beneficial studies included a small randomized controlled trial (n=20) showing improvement in 95% of patients vs 15% with placebo (p<0.0001) and a larger observational study (n=221) showing significant symptom reduction. Effects are typically observed over 4–12 weeks, though median study duration was 28 days. · Dose: 1×10^10 CFU/day3 beneficial1 neutral4 studies