Lactobacillus plantarum 299v and Improved Irritable Bowel Syndrome Symptoms

Research synthesisModerate evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Lactobacillus plantarum 299v on irritable bowel syndrome symptoms, with a predominant moderate effect size. The evidence includes a meta-analysis (n=2643) and an observational study (n=221), consistently showing improvement in global symptoms and quality of life. The primary population studied is patients with IBS, but no consistent dosing or form data were available across studies.

Studied populations: patients with IBS

Caveats: Only 3 studies identified, with one being a low-evidence review. Dosing and form were not reported, limiting practical guidance. The observational study may be subject to confounding. Duration of treatment was not consistently reported, though one study noted benefits over 12 weeks.

Generated May 11, 2026

3 of 3 papers

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
- 2026-02-02
- Review · n = 2,643
- Journal of clinical medicine 15(3)
- - Roman Maslennikov
  - Eva Gosteeva
  - Vera Ananeva
  - Lada Korshunova
  - Anastasya Kravtsowa
  - Elena Poluektova
  - Anatoly Ulyanin
  - Alexey Sigidaev
  - Patimat Kikhasurova
  - Vladimir Ivashkin
- PubMed: 41682832
- DOI: 10.3390/jcm15031152
3 Insights on
- Improved Irritable Bowel Syndrome Symptoms
- High evidence
Meta-analyses demonstrated the efficacy of Lactiplantibacillus plantarum 299v (DSM 9843) in improving key IBS symptoms.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
[Treatment of IBS with Lactobacillus plantarum 299v: Therapeutic success increases with length of treatment - real-life data of a non-interventional study in Germany].
- 2021-02
- Observational · n = 221
- Zeitschrift fur Gastroenterologie 59(02)
- - Heiner Krammer
  - Martin Storr
  - Ahmed Madisch
  - Julia Riffel
- PubMed: 33556972
- DOI: 10.1055/a-1340-0204
6 Insights on
- Improved Irritable Bowel Syndrome Symptoms
- High evidence
During the 12-week treatment, a significant and continuous reduction of overall symptom score (p < 0.05) was observed... Additionally, quality of life increased significantly... In real life, LP299V significantly alleviates the global symptoms of IBS in patients.
Effect
Beneficial
Effect size
Large
Significant
Yes
The role of Lactobacillus plantarum 299v in supporting treatment of selected diseases.
- 2021-01-25
- Review
- Central-European journal of immunology 45(4)
- - Karolina Kaźmierczak-Siedlecka
  - Agnieszka Daca
  - Marcin Folwarski
  - Jacek M Witkowski
  - Ewa Bryl
  - Wojciech Makarewicz
- PubMed: 33613097
- DOI: 10.5114/ceji.2020.101515
9 Insights on
- Improved Irritable Bowel Syndrome Symptoms
- Low evidence
The intake of L. plantarum 299v provides benefits for IBS patients, mainly due to normalization of stool and relief of abdominal pain, which significantly improves the quality of life of IBS patients.
Effect
Beneficial
Effect size
Moderate
Significant
Yes

Lactobacillus plantarum 299v and Improved Irritable Bowel Syndrome Symptoms

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.

[Treatment of IBS with Lactobacillus plantarum 299v: Therapeutic success increases with length of treatment - real-life data of a non-interventional study in Germany].

The role of Lactobacillus plantarum 299v in supporting treatment of selected diseases.