299v in supporting treatment of selected diseases.

2021-01-25
Central-European journal of immunology 45(4)
- Karolina Kaźmierczak-Siedlecka
- Agnieszka Daca
- Marcin Folwarski
- Jacek M Witkowski
- Ewa Bryl
- Wojciech Makarewicz

PubMed: 33613097
DOI: 10.5114/ceji.2020.101515

Alterations in composition of human gut microbiome can lead to its dysbiosis. It is associated with gastrointestinal side effects during anti-cancer treatment, antibiotics administration, or infectious agents. There are studies confirming positive effect of consuming Lactobacillus plantarum 299v on intestinal microflora. This review summarizes the current knowledge about the role of L. plantarum 299v in supporting treatment of selected diseases, such as cancer, irritable bowel syndrome (IBS), and Clostridium difficile infection. The immunomodulating properties of L. plantarum 299v include an increase in the level of anti-inflammatory cytokines, which reduce the risk of cancer and improve the efficacy of regimens. The intake of L. plantarum 299v provides benefits for IBS patients, mainly due to normalization of stool and relief of abdominal pain, which significantly improves the quality of life of IBS patients. In addition, the intake of L. plantarum 299v prevents C. difficile-associated diarrhea among patients receiving antibiotic treatment. Due to the limited possibilities of treating these diseases and numerous complications of cancer treatment, there is a need for new therapeutic strategies. The administration of L. plantarum 299v seems to be useful in these cases.

Research Insights

Supplement	Health Outcome	Effect Type	Effect Size
Lactobacillus plantarum 299v	Improved Gastrointestinal Microbiome Balance	Beneficial	Moderate
Lactobacillus plantarum 299v	Improved Irritable Bowel Syndrome Symptoms	Beneficial	Moderate
Lactobacillus plantarum 299v	Reduced Inflammation	Beneficial	Moderate
Lactobacillus plantarum 299v	Reduced Risk of Clostridium Difficile-Associated Diarrhea	Beneficial	Moderate