The role of Lactobacillus plantarum 299v in supporting treatment of selected diseases.

2021-01-25
Central-European journal of immunology 45(4)
- Karolina Kaźmierczak-Siedlecka
- Agnieszka Daca
- Marcin Folwarski
- Jacek M Witkowski
- Ewa Bryl
- Wojciech Makarewicz

PubMed: 33613097
DOI: 10.5114/ceji.2020.101515

Study Design

Type: Review
Methods: This review summarizes the current knowledge about the role of L. plantarum 299v in supporting treatment of selected diseases, such as cancer, irritable bowel syndrome (IBS), and Clostridium difficile infection.

Alterations in composition of human gut microbiome can lead to its dysbiosis. It is associated with gastrointestinal side effects during anti-cancer treatment, antibiotics administration, or infectious agents. There are studies confirming positive effect of consuming Lactobacillus plantarum 299v on intestinal microflora. This review summarizes the current knowledge about the role of L. plantarum 299v in supporting treatment of selected diseases, such as cancer, irritable bowel syndrome (IBS), and Clostridium difficile infection. The immunomodulating properties of L. plantarum 299v include an increase in the level of anti-inflammatory cytokines, which reduce the risk of cancer and improve the efficacy of regimens. The intake of L. plantarum 299v provides benefits for IBS patients, mainly due to normalization of stool and relief of abdominal pain, which significantly improves the quality of life of IBS patients. In addition, the intake of L. plantarum 299v prevents C. difficile-associated diarrhea among patients receiving antibiotic treatment. Due to the limited possibilities of treating these diseases and numerous complications of cancer treatment, there is a need for new therapeutic strategies. The administration of L. plantarum 299v seems to be useful in these cases.

Research Insights

Lactobacillus plantarum 299v→Improved Gastrointestinal Microbiome Balance
There are studies confirming positive effect of consuming Lactobacillus plantarum 299v on intestinal microflora.
Effect
Beneficial
Effect size
Moderate
Lactobacillus plantarum 299v→Improved Irritable Bowel Syndrome Symptoms
The intake of L. plantarum 299v provides benefits for IBS patients, mainly due to normalization of stool and relief of abdominal pain, which significantly improves the quality of life of IBS patients.
Effect
Beneficial
Effect size
Moderate
Lactobacillus plantarum 299v→Reduced Abdominal Pain
The intake of L. plantarum 299v provides benefits for IBS patients, mainly due to normalization of stool and relief of abdominal pain
Effect
Beneficial
Effect size
Moderate
Lactobacillus plantarum 299v→Reduced Diarrhea Incidence
the intake of L. plantarum 299v prevents C. difficile-associated diarrhea among patients receiving antibiotic treatment
Effect
Beneficial
Effect size
Moderate
Lactobacillus plantarum 299v→Reduced Inflammation
The immunomodulating properties of L. plantarum 299v include an increase in the level of anti-inflammatory cytokines, which reduce the risk of cancer and improve the efficacy of regimens.
Effect
Beneficial
Effect size
Moderate
Lactobacillus plantarum 299v→Reduced Risk of Clostridium Difficile-Associated Diarrhea
In addition, the intake of L. plantarum 299v prevents C. difficile-associated diarrhea among patients receiving antibiotic treatment.
Effect
Beneficial
Effect size
Moderate