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Evidence-Based Supplement Research
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Lactobacillus plantarum 299v and Reduced Abdominal Pain

Research synthesisModerate evidenceMixed effect size4 studies · 3 beneficial · 1 neutral · 0 harmful

Across 4 studies, 3 reported beneficial effects of Lactobacillus plantarum 299v on reduced abdominal pain, with one large RCT showing complete resolution of pain. Effect sizes were mixed (small to large), and the predominant finding is beneficial but inconsistent. The median study duration was 28 days (1 of 4 studies reporting), and the most studied population was irritable bowel syndrome (IBS) patients.

  • Studied populations: irritable bowel syndrome (IBS) patients

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). One large RCT (n=190) found no significant effect, conflicting with smaller positive trials. Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Most studies did not report dose or form, limiting comparability.

Generated Jul 17, 2026
Doses used in studies
  • CFU/day: 10 billion (median 10 billion, IQR 10 billion–10 billion) — 1 study
Time to effect
Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 4 studies
Safety in these studies
4 of 4 papers
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